The human genome is organized into multiple structural layers, ranging from chromosome
territories to progressively smaller substructures, such as topologically associating domains …

Membraneless biomolecular condensates play important roles in both normal life activities
and responses to environmental stimuli in living organisms. Liquid‒liquid phase separation …

Fixing cells with paraformaldehyde (PFA) is an essential step in numerous biological
techniques as it is thought to preserve a snapshot of biomolecular transactions in living cells …

Much of the human proteome is involved in mRNA homeostasis, but most RNA-binding
proteins lack chemical probes. Here we identify electrophilic small molecules that rapidly …

We report small molecular PROTAC compounds targeting the androgen receptor N-terminal
domain (AR-NTD), which were obtained by tethering AR-NTD antagonists and different …

Transcription factors are among the most attractive therapeutic targets but are considered
largely 'undruggable'in part due to the intrinsically disordered nature of their activation …

Numerous cancers, including prostate cancer (PCa), are addicted to transcription programs
driven by specific genomic regions known as super-enhancers (SEs). The robust …

Intrinsically disordered proteins (IDPs) are proteins that perform important biological
functions without well‐defined structures under physiological conditions. IDPs can form …

Transcription factors (TFs) activate enhancers to drive cell-specific gene programs in
response to signals, but our understanding of enhancer assembly during signaling events is …

The reduction in androgen synthesis and the blockade of the androgen receptor (AR)
function by chemical castration and AR signaling inhibitors represent the main treatment …