Theory and simulation of multiphase coexistence in biomolecular mixtures
WM Jacobs - Journal of Chemical Theory and Computation, 2023 - ACS Publications
Biomolecular condensates constitute a newly recognized form of spatial organization in
living cells. Although many condensates are believed to form as a result of phase …
living cells. Although many condensates are believed to form as a result of phase …
Fundamental Aspects of Phase-Separated Biomolecular Condensates
Biomolecular condensates, formed through phase separation, are upending our
understanding in much of molecular, cell, and developmental biology. There is an urgent …
understanding in much of molecular, cell, and developmental biology. There is an urgent …
[HTML][HTML] Phase separation of protein mixtures is driven by the interplay of homotypic and heterotypic interactions
Prion-like low-complexity domains (PLCDs) are involved in the formation and regulation of
distinct biomolecular condensates that form via phase separation coupled to percolation …
distinct biomolecular condensates that form via phase separation coupled to percolation …
Determinants that enable disordered protein assembly into discrete condensed phases
Cells harbour numerous mesoscale membraneless compartments that house specific
biochemical processes and perform distinct cellular functions. These protein-and RNA-rich …
biochemical processes and perform distinct cellular functions. These protein-and RNA-rich …
[HTML][HTML] Quantitative real-time in-cell imaging reveals heterogeneous clusters of proteins prior to condensation
C Lan, J Kim, S Ulferts, F Aprile-Garcia… - Nature …, 2023 - nature.com
Our current understanding of biomolecular condensate formation is largely based on
observing the final near-equilibrium condensate state. Despite expectations from classical …
observing the final near-equilibrium condensate state. Despite expectations from classical …
[HTML][HTML] Interplay between charge distribution and DNA in shaping HP1 paralog phase separation and localization
Abstract The heterochromatin protein 1 (HP1) family is a crucial component of
heterochromatin with diverse functions in gene regulation, cell cycle control, and cell …
heterochromatin with diverse functions in gene regulation, cell cycle control, and cell …
[HTML][HTML] Aromatic and arginine content drives multiphasic condensation of protein-RNA mixtures
Multiphasic architectures are found ubiquitously in biomolecular condensates and are
thought to have important implications for the organization of multiple chemical reactions …
thought to have important implications for the organization of multiple chemical reactions …
Determinants of disordered protein co-assembly into discrete condensed phases
Cells harbor numerous mesoscale membraneless compartments that house specific
biochemical processes and perform distinct cellular functions. These protein and RNA-rich …
biochemical processes and perform distinct cellular functions. These protein and RNA-rich …
Programmable phase behavior in fluids with designable interactions
We introduce a method for solving the “inverse” phase equilibria problem: How should the
interactions among a collection of molecular species be designed in order to achieve a …
interactions among a collection of molecular species be designed in order to achieve a …
[HTML][HTML] Phase separation in mixtures of prion-like low complexity domains is driven by the interplay of homotypic and heterotypic interactions
Prion-like low-complexity domains (PLCDs) are involved in the formation and regulation of
distinct biomolecular condensates that form via coupled associative and segregative phase …
distinct biomolecular condensates that form via coupled associative and segregative phase …