Pituitary gonadotrophs play a key role in reproductive functions by secreting luteinizing
hormone (LH) and follicle-stimulating hormone (FSH). The LH secretory activity of …

Activins are a subgroup of the TGFβ superfamily of growth and differentiation factors, dimeric
in nature and consisting of two inhibin beta subunits linked via a disulfide bridge. Canonical …

STUDY QUESTION Could changes in transforming growth factor β (TGFβ) signalling during
foetal ovary development alter the expression of polycystic ovary syndrome (PCOS) …

Purpose Transforming growth factor-beta receptor 3-like (TGFBR3L) is a pituitary enriched
membrane protein selectively detected in gonadotroph cells. TGFBR3L is named after …

Inhibins are members of the transforming growth factor-β family, composed of a common α-
subunit disulfide-linked to 1 of 2 β-subunits (βA in inhibin A or βB in inhibin B). Gonadal …

Injuries caused by trauma and neurodegenerative diseases can damage the peripheral
nervous system and cause functional deficits. Unlike in the central nervous system …

Although originally characterised as proteins involved in the control of reproductive function,
activins, and to a lesser degree inhibins, are also important regulators of homeostasis in …

Obesity is a chronic disease with increasing prevalence worldwide. Obesity leads to an
increased risk of heart disease, stroke, and diabetes, as well as endocrine alterations …

Isotopic labeling of methyl-substituted proteinogenic amino acids with 13C has transformed
applications of solution-based NMR spectroscopy and allowed the study of much larger and …

Testicular-derived inhibin B (α/β B dimers) acts in an endocrine manner to suppress pituitary
production of follicle-stimulating hormone (FSH), by blocking the actions of activins (β A/B/β …