Drug delivery for the treatment of endometriosis and uterine fibroids

DR Friend - Drug Delivery and Translational Research, 2017 - Springer
Endometriosis and uterine fibroids (also known as uterine leiomyomas) are serious medical
conditions affecting large numbers of women worldwide. Many women are asymptomatic but …

A comparative analysis of health-related quality of life 1 year following myomectomy or uterine artery embolization: findings from the COMPARE-UF registry

RM Anchan, D Wojdyla, P Bortoletto, K Terry… - Journal of Women's …, 2023 - liebertpub.com
Objective: To compare 12-month post-treatment health-related quality of life (HR-QoL) and
symptom severity (SS) changes among patients with symptomatic uterine fibroids (SUF) not …

[PDF][PDF] Uterine fibroid: common features of widespread tumor

V Aleksandrovych, T Bereza, M Sajewicz… - Folia medica …, 2015 - ruj.uj.edu.pl
Leiomyoma is the most frequent benign monoclonal tumor (cells behave identically in
culture) of the female reproductive system. It affected almost 50% of childbearing age …

The autonomic innervation and uterine telocyte interplay in leiomyoma formation

V Aleksandrovych, M Kurnik-Łucka… - Cell …, 2019 - journals.sagepub.com
The autonomic innervation of the uterus is involved in multiple pathophysiological processes
in both humans and animals. Pathological conditions such as adenomyosis or inflammatory …

N-of-1 policymaking—tragedy, trade-offs, and the demise of morcellation

L Rosenbaum - New England Journal of Medicine, 2016 - Mass Medical Soc
Anecdotes like those about women who receive a diagnosis of late-stage leiomyosarcoma
after morcellation of fibroids can skew risk perception, leading to estimates of outcomes' …

Gonadotropin-releasing hormone analogues inhibit leiomyoma extracellular matrix despite presence of gonadal hormones

M Malik, J Britten, J Cox, A Patel, WH Catherino - Fertility and sterility, 2016 - Elsevier
Objective To determine the effect of GnRH analogues (GnRH-a) leuprolide acetate (LA) and
cetrorelix acetate on gonadal hormone-regulated expression of extracellular matrix in …

Rational design of proteasome inhibitors based on the structure of the endogenous inhibitor PI31/Fub1

B Velez, A Razi, RD Hubbard… - Proceedings of the …, 2023 - National Acad Sciences
Proteasome inhibitors are widely used anticancer drugs. The three clinically approved
agents are modified small peptides that preferentially target one of the proteasome's three …

The Lublin Protocol of the uterine arteries embolization in the treatment of symptomatic uterine fibroids

P Szkodziak, K Pyra, F Szkodziak… - JoVE (Journal of …, 2020 - jove.com
Uterine fibroids are benign tumors originating from smooth muscle tissue, constituting
uterine muscle stroma. Uterine fibroids are the most common benign tumors found in …

Case series of seven women with uterine fibroids associated with venous thromboembolism and chronic thromboembolic disease

AS Lacharite-Roberge, F Raza, R Bashir… - Pulmonary …, 2018 - journals.sagepub.com
Uterine fibroids have been described as an associate to acute venous thromboembolism
(VTE), with case reports showing an association between large uterine fibroids, acute deep …

Women with newly diagnosed uterine fibroids: treatment patterns and cost comparison for select treatment options

MM Bonafede, SK Pohlman, JD Miller… - Population health …, 2018 - liebertpub.com
The primary objective of this study was to describe surgical treatment patterns among
women with newly diagnosed uterine fibroids (UF). A secondary objective was to estimate …