Metformin is the most commonly used treatment to increase insulin sensitivity in insulin-
resistant (IR) conditions such as diabetes, prediabetes, polycystic ovary syndrome, and …

Diabetes is a severe chronic disease that arises when insulin generation is insufficient, or
the generated insulin cannot be used in the body, resulting a long-term metabolic disorder …

Adverse childhood experiences (ACEs) may be referred to by other terms (eg, early life
adversity or stress and childhood trauma) and have a lifelong impact on mental and physical …

Glucose metabolism is normally regulated by a feedback loop including islet β cells and
insulin-sensitive tissues, in which tissue sensitivity to insulin affects magnitude of β-cell …

Diabetes mellitus is a chronic condition that occurs when the body cannot produce enough
or effectively use of insulin. Compared with individuals without diabetes, patients with type 2 …

Background Changing diet and physical activity behaviour is one of the cornerstones of type
2 diabetes treatment, but changing behaviour is challenging. The objective of this study was …

For a long time, scientists have tried to describe disorders just by genetic or environmental
factors. However, the role of epigenetics in human diseases has been considered from a …

The incidence of diabetes and its associated micro-and macrovascular complications is
greatly increasing worldwide. The most prevalent vascular complications of both type 1 and …

Epigenetic mechanisms are implicated in gene regulation and the development of different
diseases. The epigenome differs between cell types and has until now only been …

Cardiovascular diseases are the most prevalent cause of morbidity and mortality among
patients with type 1 or type 2 diabetes. The proposed mechanisms that can link accelerated …