Cancer is a multistep disease driven by the activation of specific oncogenic pathways
concomitantly with the loss of function of tumor suppressor genes that act as sentinels to …

Precise regulation of the amplitude and duration of receptor tyrosine kinase (RTK) signaling
is critical for the execution of cellular programs and behaviors. Understanding these control …

Liver X receptors (LXRs) are members of the nuclear receptor superfamily that are
canonically activated by oxidized derivatives of cholesterol. Since the mid‐90s, numerous …

The fruit fly Drosophila melanogaster has been used for modeling cancer and as an in vivo
tool for the validation and/or development of cancer therapeutics. The impetus for the use of …

The human prostate is a gland of the male reproductive tract, which together with the
seminal vesicles, is responsible for most seminal fluid production. It is a common site of …

Abstract miRNAs are small noncoding RNAs that act as critical epigenetic regulators in
tumor carcinogenesis. In this study, our data showed that miR‐137 was significantly …

MRG domain binding protein (MRGBP) has been proposed to participate in the
development of multiple tumors. However, the role of MRGBP in colorectal cancer (CRC) still …

The proper design of experiments is a critical step for each study in order to obtain
reproducible and reliable data. Taking into account constant competitiveness in the quickly …

Lung cancer is a leading cause of cancer‑related morbidity and mortality worldwide.
Although there are currently various therapeutic strategies including surgery, chemotherapy …

One of the most important but less understood step of epithelial tumourigenesis occurs when
cells acquire the ability to leave their epithelial compartment. This phenomenon, described …