Malaria treatment performance is potentially influenced by pharmacogenetic factors. This
study reports an association study between the ABCB1 c. 3435C> T, CYP3A4* 1B (g.-392A> …

Background. Several single nucleotide polymorphisms (SNPs) in the multidrug resistance
(MDR1) gene may play a role in the interindividual variation of cyclosporine A (CsA) …

A fixed-dose combination of amlodipine and olmesartan is used to treat high blood pressure
in patients whose hypertension is not sufficiently controlled with either drug alone. The …

What is known and objective Silibinin (Silybin), a major constituent of the milk thistle, is
commonly used to treat chronic liver disease in some countries. It has been reported to …

Background Hypertension, a major complication in kidney transplant recipients, is
associated with premature death and graft loss. However, an optimal antihypertensive …

Purpose Our objective was to study the effects of polymorphic the CYP3A5 (allele* 1 and* 3),
MDR1 single nucleotide polymorphisms (SNPs) G2677T, C3435T and CACNA1C (SNPs …

Background and aims The effect of multidrug resistance transporter gene 1 (MDR1) on the
bioavailability and kinetics of several substrates has not yet been fully elucidated. We …

Abstract Background/Objectives Clinical responses to naldemedine vary between
individuals with advanced cancer. This is a prospective, single‐center, observational study …

Juvenile myoclonic epilepsy (JME) is the most common of the generalized genetic
epilepsies, with multiple causal and susceptibility genes; however, its etiopathogenesis is …

Amlodipine is a racemic mixture composed of S‐and R‐form and metabolized
stereoselectively. Cytochrome P450 3A (CYP3A) including CYP3A5 are involved in the …