MDR1 C3435T 基因多态性对环孢素体内代谢影响的荟萃分析
姜志平， 王一任， 徐萍， 刘荣荣， 赵谢兰， 陈方平 - 中南药学, 2008 - cqvip.com
目的过荟萃分析进一步观察MDR1 3435T 基因多态性对于环孢素体内代谢的影响.
方法过Pubmed 搜索C3435T 基因多态性对于环孢素体内代谢影响的相关文献, 提取AUC0-4 …
方法过Pubmed 搜索C3435T 基因多态性对于环孢素体内代谢影响的相关文献, 提取AUC0-4 …
Influence of the G2677T/C3435T haplotype of MDR1 on P-glycoprotein trafficking and ibutilide-induced block of HERG
The drug efflux pump P-glycoprotein possesses two common and often linked
polymorphisms that result in variable drug action. G2677T results in A893S, whereas …
polymorphisms that result in variable drug action. G2677T results in A893S, whereas …
CYP3A activity based on plasma 4β-hydroxycholesterol during the early postpartum period has an effect on the plasma disposition of amlodipine
T Naito, N Kubono, T Ishida, S Deguchi… - Drug Metabolism and …, 2015 - Elsevier
This study aimed to evaluate plasma 4β-hydroxycholesterol as an endogenous marker of
CYP3A4/5 activity in early postpartum women and its impact on the plasma disposition of …
CYP3A4/5 activity in early postpartum women and its impact on the plasma disposition of …
P-gp 与癫 耐药相关性研究进展
顾浩， 张庆 - 中国实用神经疾病杂志, 2011 - cqvip.com
P-gp 是由ABCB1 基因编码的能量依赖性跨膜外向转运蛋白, 在灶组织内的表达明显增加,
影响AEDs 通过血脑屏障, 降低灶组织内AEDs 浓度. 给予P-gp 抑制剂, 不仅可以提高耐药细胞内 …
影响AEDs 通过血脑屏障, 降低灶组织内AEDs 浓度. 给予P-gp 抑制剂, 不仅可以提高耐药细胞内 …
[HTML][HTML] Pharmacogenomics-based individualized treatment of hypertension in preterm infants: A case report and review of the literature
LF Tang, A Xu, K Liu - World Journal of Clinical Cases, 2023 - ncbi.nlm.nih.gov
Pharmacogenomics-based individualized treatment of hypertension in preterm infants: A case
report and review of the literature - PMC Back to Top Skip to main content NIH NLM Logo …
report and review of the literature - PMC Back to Top Skip to main content NIH NLM Logo …
多药耐药基因1 C3435T 基因多态性对环孢素A 药物动力学影响的Meta 分析
李海菊， 平卫伟， 宋丽华， 郭春花， 郑王巧 - 中国组织工程研究, 2012 - cjter.com
背景: 多药耐药基因1 C3435T 基因多态性影响着P-糖蛋白的功能和表达, 从而影响环孢素A
血药浓度, 产生个体差异. 目前多药耐药基因1 C3435T 基因多态性对环孢素A …
血药浓度, 产生个体差异. 目前多药耐药基因1 C3435T 基因多态性对环孢素A …
Pharmacogenomics in Papua New Guineans: unique profiles and implications for enhancing drug efficacy while improving drug safety
Abstract Papua New Guinea (PNG) can be roughly divided into highland, coastal and island
peoples with significant mitochondrial DNA differentiation reflecting early and recent distinct …
peoples with significant mitochondrial DNA differentiation reflecting early and recent distinct …
Influence of ABCB1 gene polymorphisms on the pharmacokinetics of verapamil among healthy Chinese Han ethnic subjects
LM Zhao, XJ He, F Qiu, YX Sun… - British journal of clinical …, 2009 - Wiley Online Library
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT• The pharmacokinetics of verapamil
have been assessed in a number of studies.• As a substrate of P‐glycoprotein (P‐gp) …
have been assessed in a number of studies.• As a substrate of P‐glycoprotein (P‐gp) …
[HTML][HTML] Variantes del gen ABCB1 como factores de riesgo y factores moduladores de la edad de inicio en pacientes mexicanos con enfermedad desmielinizante
JLG Camacho, TC Vázquez, JJF Rivera, AO Morales… - Neurología, 2023 - Elsevier
Introducción Las variantes C1236T, G2677T/A y C3435T del gen ABCB1 alteran la función
de la glicoproteína P y el transporte de sustancias endógenas y exógenas en la barrera …
de la glicoproteína P y el transporte de sustancias endógenas y exógenas en la barrera …
药物基因组学在高血压药物治疗中的临床应用前景
袁洪， 蔡菁菁， 黄志军 - 心血管病学进展, 2011 - cqvip.com
高血压病及其相关的心血管疾病已成为导致死亡的首要原因之一; 但全球药物降压达标率仍较低
, 其原因之一与个体间药物疗效差异较大相关, 而药物的个体反应差异又很大程度与遗传背景 …
, 其原因之一与个体间药物疗效差异较大相关, 而药物的个体反应差异又很大程度与遗传背景 …