Objectives The aim of this study was to analyse the interplay among plasmid-mediated qnr
genes, alone or in combination with multiple chromosomal-mediated fluoroquinolone (FQ) …

Outer membrane particles from Gram-negative bacteria are attractive vaccine candidates as
they present surface antigens in their natural context. We previously developed a high yield …

黑曲霉是一种广泛存在于自然界的腐生真菌, 其分生孢子头呈褐黑色放射状,
分生孢子梗长短不一. 顶囊球形, 双层小梗(图1), 多见于粮食, 植物性产品和土壤中 …

Background & Aims Inducible chitinase 3-like-1 is expressed by intestinal epithelial cells
(IECs) and adheres to bacteria under conditions of inflammation. We performed a structure …

Summary Ileal lesions of 36.4% of patients with Crohn's disease (CD), an inflammatory
bowel disease in humans, are colonized by pathogenic adherent‐invasive Escherichia coli …

Targeted gene replacement via homologous recombination is a routinely used approach to
elucidate the function of unknown genes. Integration of exogenous DNA in the genomic …

Resistance integrons are bacterial genetic platforms that can capture and express antibiotic
resistance genes embedded within gene cassettes. The capture and shuffling of gene …

The aetiology of Crohn's disease (CD) involves disorders in host genetic factors and
intestinal microbiota. Adherent‐invasive Escherichia coli (AIEC) are receiving increased …

The type VI secretion system (T6SS) is a class of sophisticated cell contact-dependent
apparatus with anti-eukaryotic or anti-bacterial function. Klebsiella pneumoniae is one of the …

The extent of published fungal genome sequences call for sophisticated genetic tools to
address the functions and features of annotated gene products. Gene targeting is the …