Rheumatoid arthritis (RA) is characterized by inflammation and destruction of bone and
cartilage in affected joints. Autoimmune responses lead to increased osteoclastic bone …

Mechanical stimuli have fundamental roles in articular cartilage during health and disease.
Chondrocytes respond to the physical properties of the cartilage extracellular matrix (ECM) …

Osteoarthritis (OA) is the most common form of arthritis. It is characterized by progressive
destruction of articular cartilage and the development of chronic pain and constitutes a …

Transplantation of synovial fluid-derived mesenchymal stem cells (SF-MSCs) is a viable
therapy for cartilage degeneration of osteoarthritis (OA). But controlling chondrogenic …

Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease that primarily affects
the lining of the synovial joints and is associated with progressive disability, premature …

Skeletal disorders are among the leading debilitating factors affecting millions of people
worldwide. The use of stem cells for tissue repair has raised many promises in various …

Rheumatoid arthritis (RA) causes a huge medical burden due to its high morbidity and
disability rate. Emerging evidences demonstrate that RA has a tumor-like microenvironment …

Cartilage lesions and osteoarthritis (OA) presents an ever-increasing clinical and
socioeconomic burden. Synovial inflammation and articular inflammatory environment are …

Our incomplete understanding of osteoarthritis (OA) pathogenesis has significantly hindered
the development of disease-modifying therapy. The functional relationship between …

Cathepsin K (CatK) is one of the most potent proteases in lysosomal cysteine proteases
family, of which main function is to mediate bone resorption. Currently, CatK is among the …