Understanding heart development on a molecular level is a prerequisite for uncovering the
causes of congenital heart diseases. Therapeutic approaches that try to enhance cardiac …

In this review, we focus on two important steps in the formation of the embryonic heart:(i) the
progressive addition of late differentiating progenitor cells from the second heart field that …

In 2014, an extensive review discussing the major steps of cardiac development focusing on
growth, formation of primary and chamber myocardium and the development of the cardiac …

Molecular and genetic studies around the turn of this century have revolutionized the field of
cardiac development. We now know that the primary heart tube, as seen in the early embryo …

Publisher Summary This chapter discusses the findings that preceded and led to the
identification of this progenitor cell population, and different molecular and genetic …

It is now over 100years since the discovery of the cardiac conduction system, consisting of
three main parts, the sinus node, the atrioventricular node and the His–Purkinje system. The …

The conduction system of the heart initiates and coordi-nates the electric signal that causes
the rhythmic and synchronized contractions of the atria and ventricles. In higher vertebrates …

Congenital heart disease (CHD) is the most common birth defect among newborns
worldwide and contributes to significant infant morbidity and mortality. Owing to major …

The primary myocardium of the embryonic heart, including the atrioventricular canal and
outflow tract, is essential for septation and valve formation. In the chamber-forming heart, the …

Organogenesis of the vertebrate heart involves a complex sequence of events initiating with
specification and differentiation of myocardial and endocardial cells in anterior lateral …