Integrins are activatable molecules that are involved in adhesion and signalling. Of the 24
known human integrins, 3 are currently targeted therapeutically by monoclonal antibodies …

The article describes the mechanisms of action, pharmacokinetics, and pharmacodynamics
of aspirin, dipyridamole, cilostazol, the thienopyridines, and the glycoprotein IIb/IIIa …

Drug-induced immune thrombocytopenia (DITP) is a life-threatening clinical syndrome that
is under-recognized and difficult to diagnose. Many drugs can cause immune-mediated …

Idiosyncratic drug reactions are a significant cause of morbidity and mortality for patients;
they also markedly increase the uncertainty of drug development. The major targets are skin …

This article discusses platelet active drugs as part of the Seventh American College of Chest
Physicians Conference on Antithrombotic and Thrombolytic Therapy: Evidence-Based …

Drug-induced thrombocytopenia should be suspected in any patient with acute
thrombocytopenia of unknown cause. Although the incidence is low, more than 100 drugs …

The major platelet integrin, αIIbβ3, is required for platelet interactions with proteins in plasma
and the extracellular matrices (ECMs) that are essential for platelet adhesion and …

Integrins are transmembrane receptors that are central to the biology of many human
pathologies. Classically mediating cell-extracellular matrix and cell-cell interaction, and with …

This article about currently available antiplatelet drugs is part of the Antithrombotic and
Thrombolytic Therapy: American College of Chest Physicians Evidence-Based Clinical …

The platelet integrin αIIbβ3 is required for platelet aggregation. Like other integrins, αIIbβ3
resides on cell surfaces in an equilibrium between inactive and active conformations …