The requirement of the trace element selenium for life and its beneficial role in human health
has been known for several decades. This is attributed to low molecular weight selenium …

Papillary thyroid cancer (PTC) is the most prevalent form of malignancy among all cancers of
the thyroid. It is also one of the few cancers with a rapidly increasing incidence. PTC is …

Abstract The small Rho GTPase family of proteins, encompassing the three major G-protein
classes Rho, Rac and cell division control protein 42, are key mitogenic signaling molecules …

DIGE is a protein labelling and separation technique allowing quantitative proteomics of two
or more samples by optical fluorescence detection of differentially labelled proteins that are …

Quantitative proteomics is the workhorse of the modern proteomics initiative. The gel-based
and MuDPIT approaches have facilitated vital advances in the measurement of protein …

Selenium-binding protein 1 (SBP1) is a highly conserved protein that covalently binds
selenium. SBP1 may play important roles in several fundamental physiological functions …

The thyroid gland has an exceptionally high selenium content, even during selenium
deficiency. At least 11 selenoproteins are expressed, which may be involved in the …

A decade after its inception, MALDI imaging mass spectrometry has become a unique
technique in the proteomics arsenal for biomarker hunting in a variety of diseases. At this …

Vitamin D, formerly known for its role in calcium-phosphorus homeostasis, was shown to
exert a broad influence on immunity and on differentiation and proliferation processes in the …

At present, the clinical and pathological analysis used in the diagnosis of papillary thyroid
cancer (PTC) are insufficient to discern tumor behavior, and new diagnostic and prognostic …