The precise pathogenesis of immunoglobulin A nephropathy (IgAN) is still not clearly
established but emerging evidence confirms a pivotal role for mucosal immunity. This review …

It is commonly stated that mucosal immunity plays a role in the pathogenesis of IgA
nephropathy (IgAN); however, the search for specific eliciting factors has been largely …

Recent data suggest that gut-associated lymphoid tissue (GALT) plays a major role in the
development of immunoglobulin A (IgA) nephropathy (IgAN). A genome-wide association …

We investigated Toll-like receptors (TLR-3,-4 and-7) expression in circulating mononuclear
cells of patients with immunoglobulin A nephropathy (IgAN), a disease with debated …

IgA nephropathy (IgAN) is the most common form of primary glomerulonephritis worldwide,
exhibiting a variable clinical and pathological course and significantly contributing to the …

Complement activation has a deep pathogenic influence in immunoglobulin (Ig) A
nephropathy (IgAN). C3a and C5a, small cleavage fragments generated by complement …

Background and aim IgA nephropathy is one of the leading causes of primary
glomerulonephritis worldwide and an important etiology of renal disease in young adults …

A hallmark of immunoglobulin A nephropathy (IgAN) is episodes of gross hematuria
coinciding with mucosal infections that can represent the disease-triggering event. Here we …

In order to present an antigen to T-cells, the antigen must first be degraded by proteasomes.
Following exposure to interferons, some proteasome subunits (ß1, ß2, ß5) are replaced by …

Previous studies have shown that secretory IgA (sIgA) was critically involved in IgA
nephropathy (IgAN) immune responses. Toll-like receptors (TLRs), especially TLR4 which …