Tumor microenvironment: barrier or opportunity towards effective cancer therapy
Tumor microenvironment (TME) is a specialized ecosystem of host components, designed
by tumor cells for successful development and metastasis of tumor. With the advent of 3D …
by tumor cells for successful development and metastasis of tumor. With the advent of 3D …
Challenges in neoantigen-directed therapeutics
L Lybaert, S Lefever, B Fant, E Smits, B De Geest… - Cancer Cell, 2023 - cell.com
A fundamental prerequisite for the efficacy of cancer immunotherapy is the presence of
functional, antigen-specific T cells within the tumor. Neoantigen-directed therapy is a …
functional, antigen-specific T cells within the tumor. Neoantigen-directed therapy is a …
Mismatch repair deficiency is not sufficient to elicit tumor immunogenicity
PMK Westcott, F Muyas, H Hauck, OC Smith… - Nature Genetics, 2023 - nature.com
DNA mismatch repair deficiency (MMRd) is associated with a high tumor mutational burden
(TMB) and sensitivity to immune checkpoint blockade (ICB) therapy. Nevertheless, most …
(TMB) and sensitivity to immune checkpoint blockade (ICB) therapy. Nevertheless, most …
NetMHCpan-4.1 and NetMHCIIpan-4.0: improved predictions of MHC antigen presentation by concurrent motif deconvolution and integration of MS MHC eluted ligand …
Major histocompatibility complex (MHC) molecules are expressed on the cell surface, where
they present peptides to T cells, which gives them a key role in the development of T-cell …
they present peptides to T cells, which gives them a key role in the development of T-cell …
A transformer-based model to predict peptide–HLA class I binding and optimize mutated peptides for vaccine design
Human leukocyte antigen (HLA) can recognize and bind foreign peptides to present them to
specialized immune cells, then initiate an immune response. Computational prediction of the …
specialized immune cells, then initiate an immune response. Computational prediction of the …
A large peptidome dataset improves HLA class I epitope prediction across most of the human population
Prediction of HLA epitopes is important for the development of cancer immunotherapies and
vaccines. However, current prediction algorithms have limited predictive power, in part …
vaccines. However, current prediction algorithms have limited predictive power, in part …
Evolution of neoantigen landscape during immune checkpoint blockade in non–small cell lung cancer
Immune checkpoint inhibitors have shown significant therapeutic responses against tumors
containing increased mutation-associated neoantigen load. We have examined the evolving …
containing increased mutation-associated neoantigen load. We have examined the evolving …
Distinct patterns of somatic genome alterations in lung adenocarcinomas and squamous cell carcinomas
To compare lung adenocarcinoma (ADC) and lung squamous cell carcinoma (SqCC) and to
identify new drivers of lung carcinogenesis, we examined the exome sequences and copy …
identify new drivers of lung carcinogenesis, we examined the exome sequences and copy …
Low neoantigen expression and poor T-cell priming underlie early immune escape in colorectal cancer
Immune evasion is a hallmark of cancer and therapies that restore immune surveillance
have proven highly effective in cancers with high tumor mutation burden (TMB)(for example …
have proven highly effective in cancers with high tumor mutation burden (TMB)(for example …
Mass spectrometry profiling of HLA-associated peptidomes in mono-allelic cells enables more accurate epitope prediction
Identification of human leukocyte antigen (HLA)-bound peptides by liquid chromatography-
tandem mass spectrometry (LC-MS/MS) is poised to provide a deep understanding of rules …
tandem mass spectrometry (LC-MS/MS) is poised to provide a deep understanding of rules …