Tuberculosis (TB) is a contagious disease that predominantly affects the lungs, but can also
spread to other organs via the bloodstream. TB affects about one-fourth population of the …

Birdshot Uveitis (BU) is a blinding inflammatory eye condition that only affects HLA-A29-
positive individuals. Genetic association studies linked ERAP2 with BU, an aminopeptidase …

Genetic variation in the peptide-binding groove of the highly polymorphic HLA class I
molecules has repeatedly been associated with HIV-1 control and progression to AIDS …

String-of-beads polypeptides allow convenient delivery of epitope-based vaccines. The
success of a polypeptide relies on efficient processing: constituent epitopes need to be …

Assessment of protective or harmful T cell response induced by any antigenic epitope is
important in designing any immunotherapeutic molecule. The understanding of cytokine …

Malignant melanoma is the most aggressive and life-threaten skin cancer. Nowadays, the
prevention and treatment of melanoma are challenging areas for researchers and …

Accurate prediction of TCR-pMHC binding is important for the development of cancer
immunotherapies, especially TCR-based agents. Existing algorithms often experience …

The development of autoimmune diseases following SARS-CoV-2 infection, including
multisystem inflammatory syndrome, has been reported, and several mechanisms have …

Background Polymorphic differences between human leukocyte antigen (HLA) molecules
affect the specificity and conformation of their bound peptides and lead to differential …

In this chapter, we review the computational approaches that have led to a new generation
of vaccines in recent years. There are many alternative routes to develop vaccines based on …