The VEGF/VEGFR axis revisited: implications for cancer therapy
P Mabeta, V Steenkamp - International journal of molecular sciences, 2022 - mdpi.com
The vascular endothelial growth factor (VEGF)/vascular endothelial growth factor receptor
(VEGFR) axis is indispensable in the process of angiogenesis and has been implicated as a …
(VEGFR) axis is indispensable in the process of angiogenesis and has been implicated as a …
Exosomes and cancer: from molecular mechanisms to clinical applications
Exosomes are extracellular nanovesicles secreted from almost all types of normal and
cancer cells. Collective evidence suggests that exosomes participate in cell–cell …
cancer cells. Collective evidence suggests that exosomes participate in cell–cell …
A computational framework for the inference of protein complex remodeling from whole-proteome measurements
Protein complexes are responsible for the enactment of most cellular functions. For the
protein complex to form and function, its subunits often need to be present at defined …
protein complex to form and function, its subunits often need to be present at defined …
[HTML][HTML] Next-generation drug repurposing using human genetics and network biology
S Nabirotchkin, AE Peluffo, P Rinaudo, J Yu… - Current Opinion in …, 2020 - Elsevier
Drug repurposing has attracted increased attention, especially in the context of drug
discovery rates that remain too low despite a recent wave of approvals for biological …
discovery rates that remain too low despite a recent wave of approvals for biological …
[HTML][HTML] Novel metal nanomaterials to promote angiogenesis in tissue regeneration
YG Yoshida, S Yan, H Xu, J Yang - Engineered regeneration, 2023 - Elsevier
Angiogenesis—the formation of new blood vessels from existing blood vessels—has drawn
significant attention in medical research. New techniques have been developed to control …
significant attention in medical research. New techniques have been developed to control …
Mechanistic insight into activation of MAPK signaling by pro-angiogenic factors
Background Angiogenesis is important in physiological and pathological conditions, as
blood vessels provide nutrients and oxygen needed for tissue growth and survival …
blood vessels provide nutrients and oxygen needed for tissue growth and survival …
A peptide mimicking the binding sites of VEGF-A and VEGF-B inhibits VEGFR-1/-2 driven angiogenesis, tumor growth and metastasis
M Farzaneh Behelgardi, S Zahri, F Mashayekhi… - Scientific reports, 2018 - nature.com
Interfering with interactions of vascular endothelial growth factors (VEGFs) with their
receptors (VEGFRs) effectively inhibits angiogenesis and tumor growth. We designed an …
receptors (VEGFRs) effectively inhibits angiogenesis and tumor growth. We designed an …
A data-driven computational model enables integrative and mechanistic characterization of dynamic macrophage polarization
Macrophages are highly plastic immune cells that dynamically integrate microenvironmental
signals to shape their own functional phenotypes, a process known as polarization. Here we …
signals to shape their own functional phenotypes, a process known as polarization. Here we …
Recent advances of anti-angiogenic inhibitors targeting VEGF/VEGFR axis
Vascular endothelial growth factors (VEGF), Vascular endothelial growth factor receptors
(VEGFR) and their downstream signaling pathways are promising targets in anti-angiogenic …
(VEGFR) and their downstream signaling pathways are promising targets in anti-angiogenic …
VEGF-A splice variants bind VEGFRs with differential affinities
SB Mamer, A Wittenkeller, PI Imoukhuede - Scientific reports, 2020 - nature.com
Vascular endothelial growth factor A (VEGF-A) and its binding to VEGFRs is an important
angiogenesis regulator, especially the earliest-known isoform, VEGF-A165a. Yet several …
angiogenesis regulator, especially the earliest-known isoform, VEGF-A165a. Yet several …