Ubiquitination, an important type of protein posttranslational modification (PTM), plays a
crucial role in controlling substrate degradation and subsequently mediates the “quantity” …

Blocking the biological functions of scaffold proteins and aggregated proteins is a
challenging goal. PROTAC proteolysis-targeting chimaera (PROTAC) technology may be …

Background Cancer is a heterogeneous disease with many genetic variations. Lines of
evidence have shown copy number variations (CNVs) of certain genes are involved in …

The pathophysiological roles and the therapeutic potentials of Myc family are reviewed in
this article. The physiological functions and molecular machineries in stem cells, including …

As the ubiquitin–proteasome system (UPS) regulates almost every biological process, the
dysregulation or aberrant expression of the UPS components causes many pathological …

P53 deficiency affects cholesterol esterification to exacerb... : Hepatology P53 deficiency affects
cholesterol esterification to exacerbate hepatocarcinogenesis : Hepatology AASLD Publications …

Simple Summary The ubiquitin-proteasome system regulates multiple facets of protein
homeostasis to modulate signal transduction in numerous biological processes. Not …

Breast cancer has the highest incidence and death rate among cancers in women
worldwide. In particular, metastatic estrogen receptor negative (ER–) breast cancer and …

Krüppel-like factor 4 (KLF4), a key transcription factor, acts as a multifunctional player
involved in the progression of numerous aggressive cancers. The proteasome-dependent …

The advent of T-cell-based immunotherapy has remarkably transformed cancer patient
treatment. Despite their success, the currently approved immunotherapeutic protocols still …