[HTML][HTML] Effectiveness and safety of atezolizumab-bevacizumab in patients with unresectable hepatocellular carcinoma: a systematic review and meta-analysis

AV Kulkarni, H Tevethia, K Kumar, M Premkumar… - …, 2023 - thelancet.com
Background Atezolizumab-bevacizumab (atezo-bev) is recommended as first-line therapy
for patients with unresectable hepatocellular carcinoma (uHCC). However, its effectiveness …

[PDF][PDF] Preliminary evidence of safety and tolerability of atezolizumab plus bevacizumab in patients with hepatocellular carcinoma and Child‐Pugh A and B cirrhosis: a …

A D'Alessio, CAM Fulgenzi, N Nishida… - …, 2022 - Wiley Online Library
Abstract Background and Aims Atezolizumab plus bevacizumab (AtezoBev) is the standard
of care for first‐line treatment of unresectable HCC. No evidence exists as to its use in …

[HTML][HTML] New advances in the research of clinical treatment and novel anticancer agents in tumor angiogenesis

X Li, J Zhou, X Wang, C Li, Z Ma, Q Wan… - Biomedicine & …, 2023 - Elsevier
In 1971, Folkman proposed that tumors could be limited to very small sizes by blocking
angiogenesis. Angiogenesis is the generation of new blood vessels from pre-existing …

Therapeutic efficacy of atezolizumab plus bevacizumab treatment for unresectable hepatocellular carcinoma in patients with child‐Pugh class a or B liver function in …

T Tanaka, A Hiraoka, T Tada, M Hirooka… - Hepatology …, 2022 - Wiley Online Library
Abstract Background/Aim Atezolizumab plus bevacizumab (Atez/Bev) treatment is
recommended for unresechepatocellular carcinoma (u‐HCC) patients classified as Child …

Association of high levels of antidrug antibodies against atezolizumab with clinical outcomes and T-cell responses in patients with hepatocellular carcinoma

C Kim, H Yang, I Kim, B Kang, H Kim, H Kim… - JAMA …, 2022 - jamanetwork.com
Importance Administration of atezolizumab could be immunogenic and induce undesirable
antidrug antibody (ADA) responses. This may interfere with atezolizumab-mediated actions …

[HTML][HTML] High serum IL-6 correlates with reduced clinical benefit of atezolizumab and bevacizumab in unresectable hepatocellular carcinoma

H Yang, B Kang, Y Ha, SH Lee, I Kim, H Kim, WS Lee… - JHEP Reports, 2023 - Elsevier
Background & Aims We elucidated the clinical and immunologic implications of serum IL-6
levels in patients with unresectable hepatocellular carcinoma (HCC) treated with …

Predictive biomarkers of survival in patients with advanced hepatocellular carcinoma receiving atezolizumab plus bevacizumab treatment

YE Chon, J Cheon, H Kim, B Kang, Y Ha… - Cancer …, 2023 - Wiley Online Library
Background Since atezolizumab plus bevacizumab (ATE+ BEV) regimen for patients with
unresectable hepatocellular carcinoma (HCC) was released quite recently, real‐world data …

[HTML][HTML] Intensity-modulated radiotherapy combined with systemic atezolizumab and bevacizumab in treatment of hepatocellular carcinoma with extrahepatic portal …

K Wang, YJ Xiang, HM Yu, YQ Cheng, ZH Liu… - Frontiers in …, 2023 - frontiersin.org
Background and aims The efficacy and safety of systemic atezolizumab and bevacizumab
(atezo/bev) in treatment of patients with unresectable hepatocellular carcinoma (HCC) have …

[HTML][HTML] Efficacy and safety of atezolizumab plus bevacizumab treatment for advanced hepatocellular carcinoma in the real world: a single-arm meta-analysis

X Gao, R Zhao, H Ma, S Zuo - BMC cancer, 2023 - Springer
Background Atezolizumab plus bevacizumab was approved in 2020 as a first-line treatment
for advanced hepatocellular carcinoma (HCC). The purpose of this study was to assess the …

[HTML][HTML] Could we predict the response of immune checkpoint inhibitor treatment in hepatocellular carcinoma?

C Lee, SL Chan, HJ Chon - Cancers, 2022 - mdpi.com
Simple Summary The use of anti-programmed cell-death protein (ligand)-1 (PD-[L] 1) is now
a standard of care for treating hepatocellular carcinoma (HCC). However, the treatment only …