Pancreatic islets are richly vascularized, and islet blood vessels are uniquely adapted to
maintain and support the internal milieu of the islets favoring normal endocrine function. Islet …

Islet transplantation may be used to treat type I diabetes. Despite tremendous progress in
islet isolation, culture, and preservation, the clinical use of this modality of treatment is …

Endothelial cells (ECs) are a key cellular component of the vascular system as they form the
inner lining of the blood vessels. Recent findings highlight that ECs express extensive …

Studies on diabetes have long been hampered by a lack of authentic disease models that,
ideally, should be unlimited and able to recapitulate the abnormalities involved in the …

Type 1 diabetes is an insulin-dependent, autoimmune disease where the pancreatic β cells
are destroyed resulting in hyperglycemia. This multifactorial disease involves multiple …

The mechanisms underlying early islet graft failure are not entirely clear, but are thought to
involve ischemic injury due to delayed vascularization. We hypothesize that blood vessels …

Pancreatic islet transplantation is a promising treatment for type 1 diabetes. However,
viability and functionality of the islets after transplantation are limited due to loss of integrity …

Pancreatic islet transplantation is one of the options for treating diabetes and has been
shown to improve the quality of life of severe diabetic patients. Since the Edmonton protocol …

Aim: Delayed graft revascularization impedes the success of human islet transplantation.
This study utilized rotational co‐culture of insulin secreting β‐cells with human umbilical vein …

The incretin hormone glucose‐dependent insulinotropic polypeptide (GIP) potentiates
glucose‐stimulated insulin secretion, and affects β‐cell turnover. This study aimed at …