[HTML][HTML] Diabetic retinopathy: current understanding, mechanisms, and treatment strategies

EJ Duh, JK Sun, AW Stitt - JCI insight, 2017 - ncbi.nlm.nih.gov
Diabetic retinopathy (DR) causes significant visual loss on a global scale. Treatments for the
vision-threatening complications of diabetic macular edema (DME) and proliferative diabetic …

Retinal ganglion cell repopulation for vision restoration in optic neuropathy: a roadmap from the RReSTORe Consortium

JR Soucy, EA Aguzzi, J Cho, MJ Gilhooley… - Molecular …, 2023 - Springer
Retinal ganglion cell (RGC) death in glaucoma and other optic neuropathies results in
irreversible vision loss due to the mammalian central nervous system's limited regenerative …

Pathologically high intraocular pressure disturbs normal iron homeostasis and leads to retinal ganglion cell ferroptosis in glaucoma

F Yao, J Peng, E Zhang, D Ji, Z Gao, Y Tang… - Cell Death & …, 2023 - nature.com
Glaucoma can result in retinal ganglion cell (RGC) death and permanently damaged vision.
Pathologically high intraocular pressure (ph-IOP) is the leading cause of damaged vision …

Anti‐PANoptosis is involved in neuroprotective effects of melatonin in acute ocular hypertension model

D Ye, Y Xu, Y Shi, M Fan, P Lu, X Bai… - Journal of Pineal …, 2022 - Wiley Online Library
Acute ocular hypertension (AOH) is the most important characteristic of acute glaucoma,
which can lead to retinal ganglion cell (RGC) death and permanent vision loss. So far …

[HTML][HTML] Metformin protects against retinal ischemia/reperfusion injury through AMPK-mediated mitochondrial fusion

K Zhang, T Wang, GF Sun, JX Xiao, LP Jiang… - Free Radical Biology …, 2023 - Elsevier
Retinal ischemia/reperfusion (I/R) injury is a common pathological process responsible for
cellular damage in glaucoma, diabetic retinopathy and hypertensive retinopathy. Metformin …

[HTML][HTML] Osteopontin drives retinal ganglion cell resiliency in glaucomatous optic neuropathy

M Zhao, K Toma, B Kinde, L Li, AK Patel, KY Wu… - Cell reports, 2023 - cell.com
Chronic neurodegeneration and acute injuries lead to neuron losses via diverse processes.
We compared retinal ganglion cell (RGC) responses between chronic glaucomatous …

Brimonidine is neuroprotective in animal paradigm of retinal ganglion cell damage

F Conti, GL Romano, CM Eandi, MD Toro… - Frontiers in …, 2021 - frontiersin.org
To investigate the neuroprotective effect of brimonidine after retinal ischemia damage on
mouse eye. Glaucoma is an optic neuropathy characterized by retinal ganglion cells (RGCs) …

Pyroptosis in the retinal neurovascular unit: new insights into diabetic retinopathy

C Meng, C Gu, S He, T Su, T Lhamo, D Draga… - Frontiers in …, 2021 - frontiersin.org
Diabetic retinopathy (DR) is prevalent among people with long-term diabetes mellitus (DM)
and remains the leading cause of visual impairment in working-aged people. DR is related …

Delineating effects of angiopoietin-2 inhibition on vascular permeability and inflammation in models of retinal neovascularization and ischemia/reperfusion

J Canonica, R Foxton, MG Garrido, CM Lin… - Frontiers in Cellular …, 2023 - frontiersin.org
Introduction Clinical trials demonstrated that co-targeting angiopoietin-2 (Ang-2) and
vascular endothelial growth factor (VEGF-A) with faricimab controls anatomic outcomes and …

Treatment of glaucoma with natural products and their mechanism of action: An update

RH Sim, SR Sirasanagandla, S Das, SL Teoh - Nutrients, 2022 - mdpi.com
Glaucoma is one of the leading causes of irreversible blindness. It is generally caused by
increased intraocular pressure, which results in damage of the optic nerve and retinal …