Contribution of epididymal epithelial cell functions to sperm epigenetic changes and the health of progeny

H Chen, MBR Alves… - Human reproduction …, 2022 - academic.oup.com
BACKGROUND Spermatozoa acquire their motility and fertilizing abilities during their
maturation through the epididymis. This process is controlled by epididymal epithelial cells …

Microenvironment for spermatogenesis and sperm maturation

H Miyaso, Y Ogawa, M Itoh - Histochemistry and cell biology, 2022 - Springer
The male reproductive system consists of testes, a series of ducts connecting the testes to
the external urethral orifice, accessory sex glands, and the penis. Spermatogonial stem cells …

[HTML][HTML] Embryology, testicle

OA Titi-Lartey, YS Khan - 2020 - europepmc.org
This article will review the embryological development of the testicles. However, to
understand the embryology of the testicles, it is essential to have a basic understanding of …

Severe acute respiratory syndrome coronavirus 2 and male reproduction: relationship, explanations, and clinical remedies

J Xu, L He, Y Zhang, Z Hu, Y Su, Y Fang… - Frontiers in …, 2021 - frontiersin.org
Coronavirus disease 2019 (COVID-2019) caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) has been an ongoing pandemic and worldwide public health …

Epididymal embryonic development harbors TLR4/NFKB signaling pathway as a morphogenetic player

LGA Ferreira, FA Nishino, SG Fernandes… - Journal of Reproductive …, 2022 - Elsevier
The Wolffian duct (WD) is an embryonic tissue that undergoes androgen-induced
morphological changes to become the epididymis. Toll-like receptor 4 (TLR4)-and nuclear …

Lipopolysaccharide-induced epididymitis modifies the transcriptional profile of Wfdc genes in mice

AD Andrade, PGC Almeida, NAP Mariani… - Biology of …, 2021 - academic.oup.com
Whey-acidic protein four-disulfide core domain (WFDC) genes display putative roles in
innate immunity and fertility. In mice, a locus on chromosome 2 contains 5 and 11 Wfdc …

Involvement of porcine β-defensin 129 in sperm capacitation and rescue of poor sperm in genital tract infection

F Zeng, M Wang, J Li, C Li, X Pan, L Meng, L Li… - International Journal of …, 2022 - mdpi.com
In mammals, β-defensins have been reported to play pivotal roles in sperm protection and
fertilization. However, the function and mechanism of porcine β-defensin 129 (pBD129) in …

Thiolutin, a selective NLRP3 inflammasome inhibitor, attenuates cyclophosphamide–induced impairment of sperm and fertility in mice

P Zhu, X Bi, D Su, X Li, B Chen, J Li… - …, 2024 - Taylor & Francis
Objective The activation of the NLRP3 inflammasome has been implicated in male infertility.
Our study aimed to investigate the therapeutic role of Thiolutin (THL), an inhibitor of the …

Assessment of progesterone synthesis and its regulation role on dihydrotestosterone secretion in sheep epididymis

J Hu, W Ge, L Xiao, J Zeng, J Lv, Z Ding, W Wang… - Gene, 2021 - Elsevier
Progesterone (P4) is an anti-androgen compound whose role in sperm maturation and
functionality remains unclear in sheep. Here, we aimed to investigate the regulation …

Distinct expression and localization patterns of HSP70 in developmental reproductive organs of rams

X Wang, T Li, N Chen, X An, X Zhao, Y Ma - Gene, 2020 - Elsevier
Abstract Heat shock protein 70 (HSP70) has been widely reported to play a vital role in
maintaining intracellular homeostasis, mainly through cellular protection and immune …