Defects in the major histocompatibility complex (MHC) class I antigen-processing machinery
(APM) have been described in tumors of different histology. Murine data suggest that defects …

Major histocompatibility complex class II antigen presentation requires the participation of
lysosomal proteases in two convergent processes. First, the antigens endocytosed by the …

Association of major histocompatibility complex (MHC) class II molecules with peptides
occurs in a series of endocytic vacuoles, termed MHC class II-enriched compartments …

Dendritic cells (DC) efficiently take up antigens by macropinocytosis and mannose receptor‐
mediated endocytosis. Here we show that endocytosis of mannose receptor‐antigen …

HLA-DR molecules bind microbial peptides in an endosomal compartment and present
them on the cell surface for CD4 T cell surveillance. HLA-DM plays a critical role in the …

HLA-DM is a major histocompatibility complex (MHC) class II–like molecule that facilitates
antigen processing by catalyzing the exchange of invariant chain–derived peptides (CLIP) …

Antigen presentation by major histocompatibility complex (MHC) class II molecules requires
the participation of different proteases in the endocytic route to degrade endocytosed …

Antigenic peptide loading of classical major histocompatibility complex (MHC) class II
molecules requires the exchange of the endogenous invariant chain fragment CLIP (class II …

H2-M is a nonconventional major histocompatibility complex (MHC) class II molecule that
has been implicated in the loading of peptides onto conventional class II molecules. We …

Dendritic cells (DCs) are central to the maintenance of immunological tolerance and the
initiation and control of immunity. The antigen-presenting properties of DCs enable them to …