Antigen-processing machinery breakdown and tumor growth
B Seliger, MJ Maeurer, S Ferrone - Immunology today, 2000 - cell.com
Defects in the major histocompatibility complex (MHC) class I antigen-processing machinery
(APM) have been described in tumors of different histology. Murine data suggest that defects …
(APM) have been described in tumors of different histology. Murine data suggest that defects …
Proteases involved in MHC dass II antigen presentation
JA Villadangos, RAR Bryant, J Deussing… - Immunological …, 1999 - Wiley Online Library
Major histocompatibility complex class II antigen presentation requires the participation of
lysosomal proteases in two convergent processes. First, the antigens endocytosed by the …
lysosomal proteases in two convergent processes. First, the antigens endocytosed by the …
Selective enrichment of tetraspan proteins on the internal vesicles of multivesicular endosomes and on exosomes secreted by human B-lymphocytes
JM Escola, MJ Kleijmeer, W Stoorvogel… - Journal of Biological …, 1998 - ASBMB
Association of major histocompatibility complex (MHC) class II molecules with peptides
occurs in a series of endocytic vacuoles, termed MHC class II-enriched compartments …
occurs in a series of endocytic vacuoles, termed MHC class II-enriched compartments …
Mannose receptor‐mediated uptake of antigens strongly enhances HLA class II‐restricted antigen presentation by cultured dendritic cells
MCAA Tan, AM Mommaas, JW Drijfhout… - European journal of …, 1997 - Wiley Online Library
Dendritic cells (DC) efficiently take up antigens by macropinocytosis and mannose receptor‐
mediated endocytosis. Here we show that endocytosis of mannose receptor‐antigen …
mediated endocytosis. Here we show that endocytosis of mannose receptor‐antigen …
[HTML][HTML] Crystal structure of the HLA-DM–HLA-DR1 complex defines mechanisms for rapid peptide selection
HLA-DR molecules bind microbial peptides in an endosomal compartment and present
them on the cell surface for CD4 T cell surveillance. HLA-DM plays a critical role in the …
them on the cell surface for CD4 T cell surveillance. HLA-DM plays a critical role in the …
Negative regulation by HLA-DO of MHC class II-restricted antigen processing
LK Denzin, DB Sant'Angelo, C Hammond, MJ Surman… - Science, 1997 - science.org
HLA-DM is a major histocompatibility complex (MHC) class II–like molecule that facilitates
antigen processing by catalyzing the exchange of invariant chain–derived peptides (CLIP) …
antigen processing by catalyzing the exchange of invariant chain–derived peptides (CLIP) …
Cathepsins B and D are dispensable for major histocompatibility complex class II-mediated antigen presentation
J Deussing, W Roth, P Saftig, C Peters… - Proceedings of the …, 1998 - National Acad Sciences
Antigen presentation by major histocompatibility complex (MHC) class II molecules requires
the participation of different proteases in the endocytic route to degrade endocytosed …
the participation of different proteases in the endocytic route to degrade endocytosed …
Editing of the HLA‐DR‐peptide repertoire by HLA‐DM.
H Kropshofer, AB Vogt, G Moldenhauer… - The EMBO …, 1996 - embopress.org
Antigenic peptide loading of classical major histocompatibility complex (MHC) class II
molecules requires the exchange of the endogenous invariant chain fragment CLIP (class II …
molecules requires the exchange of the endogenous invariant chain fragment CLIP (class II …
[HTML][HTML] H2-M mutant mice are defective in the peptide loading of class II molecules, antigen presentation, and T cell repertoire selection
WD Martin, GG Hicks, SK Mendiratta, HI Leva… - Cell, 1996 - cell.com
H2-M is a nonconventional major histocompatibility complex (MHC) class II molecule that
has been implicated in the loading of peptides onto conventional class II molecules. We …
has been implicated in the loading of peptides onto conventional class II molecules. We …
Regulation of antigen presentation and cross-presentation in the dendritic cell network: facts, hypothesis, and immunological implications
NS Wilson, JA Villadangos - Advances in immunology, 2005 - Elsevier
Dendritic cells (DCs) are central to the maintenance of immunological tolerance and the
initiation and control of immunity. The antigen-presenting properties of DCs enable them to …
initiation and control of immunity. The antigen-presenting properties of DCs enable them to …