Progress on Ras/MAPK signaling research and targeting in blood and solid cancers
M Dillon, A Lopez, E Lin, D Sales, R Perets, P Jain - Cancers, 2021 - mdpi.com
Simple Summary The Ras-Raf-MEK-ERK signaling pathway is responsible for regulating
cell proliferation, differentiation, and survival. Overexpression and overactivation of …
cell proliferation, differentiation, and survival. Overexpression and overactivation of …
Clinical utility of pegaspargase in children, adolescents and young adult patients with acute lymphoblastic leukemia: a review
C Bender, L Maese, M Carter-Febres… - Blood and Lymphatic …, 2021 - Taylor & Francis
Acute lymphoblastic leukemia (ALL) is a heterogenous hematological malignancy
representing 25% of all cancers in children less than 15 years of age. Significant …
representing 25% of all cancers in children less than 15 years of age. Significant …
Long-term follow-up of donor-derived CD7 CAR T-cell therapy in patients with T-cell acute lymphoblastic leukemia
Y Tan, L Shan, L Zhao, B Deng, Z Ling, Y Zhang… - Journal of Hematology & …, 2023 - Springer
Background Donor-derived CD7-directed chimeric antigen receptor (CAR) T cells showed
feasibility and early efficacy in patients with refractory or relapsed T-cell acute lymphoblastic …
feasibility and early efficacy in patients with refractory or relapsed T-cell acute lymphoblastic …
Favorable activity and safety profile of memory-enriched CD19-targeted chimeric antigen receptor T-cell therapy in adults with high-risk relapsed/refractory ALL
I Aldoss, SK Khaled, X Wang, J Palmer, Y Wang… - Clinical Cancer …, 2023 - AACR
Abstract Purpose: A phase I/II study evaluating the safety and activity of memory-enriched
CD19-directed chimeric antigen receptor (CD19-CAR) T cells in adults with …
CD19-directed chimeric antigen receptor (CD19-CAR) T cells in adults with …
[HTML][HTML] Impact of the national drug price negotiation policy on the utilization, cost, and accessibility of anticancer medicines in China: a controlled interrupted time …
L Cai, T Tao, H Li, Z Zhang, L Zhang, X Li - Journal of global health, 2022 - ncbi.nlm.nih.gov
Background China implemented the national drug price negotiation (NDPN) policy to
include 17 innovative anticancer medicines in the national reimbursement drug list in 2018 …
include 17 innovative anticancer medicines in the national reimbursement drug list in 2018 …
MTXPK. org: a clinical decision support tool evaluating high‐dose methotrexate pharmacokinetics to inform post‐infusion care and use of glucarpidase
Methotrexate (MTX), an antifolate, is administered at high doses to treat malignancies in
children and adults. However, there is considerable interpatient variability in clearance of …
children and adults. However, there is considerable interpatient variability in clearance of …
A validated pediatric disease risk index for allogeneic hematopoietic cell transplantation
M Qayed, KW Ahn, CL Kitko… - Blood, The Journal …, 2021 - ashpublications.org
A disease risk index (DRI) that was developed for adults with hematologic malignancy who
were undergoing hematopoietic cell transplantation is also being used to stratify children …
were undergoing hematopoietic cell transplantation is also being used to stratify children …
Diagnosis, grading and management of toxicities from immunotherapies in children, adolescents and young adults with cancer
D Ragoonanan, SJ Khazal, H Abdel-Azim… - Nature Reviews …, 2021 - nature.com
Cancer immunotherapies are associated with remarkable therapeutic response rates but
also with unique and severe toxicities, which potentially result in rapid deterioration in …
also with unique and severe toxicities, which potentially result in rapid deterioration in …
6-Thioguanosine monophosphate prodrugs display enhanced performance against thiopurine-resistant leukemia and breast cancer cells
Thiopurines are in widespread clinical use for the treatment of immunological disorders and
certain cancers. However, treatment failure due to resistance or adverse drug reactions are …
certain cancers. However, treatment failure due to resistance or adverse drug reactions are …
Minimal residual disease detection by next-generation sequencing of different immunoglobulin gene rearrangements in pediatric B-ALL
H Chen, M Gu, J Liang, H Song, J Zhang, W Xu… - Nature …, 2023 - nature.com
While the prognostic role of immunoglobulin heavy chain locus (IGH) rearrangement in
minimal residual disease (MRD) in pediatric B-acute lymphoblastic leukemia (B-ALL) has …
minimal residual disease (MRD) in pediatric B-acute lymphoblastic leukemia (B-ALL) has …