Transcription factor GLIS3: Critical roles in thyroid hormone biosynthesis, hypothyroidism, pancreatic beta cells and diabetes
DW Scoville, HS Kang, AM Jetten - Pharmacology & therapeutics, 2020 - Elsevier
ABSTRACT GLI-Similar 3 (GLIS3) is a member of the GLIS subfamily of Krüppel-like zinc
finger transcription factors that functions as an activator or repressor of gene expression …
finger transcription factors that functions as an activator or repressor of gene expression …
Updates on genes and genetic mechanisms implicated in primary angle-closure glaucoma
AA Kondkar - The application of clinical genetics, 2021 - Taylor & Francis
Primary angle-closure glaucoma (PACG) is estimated to affect over 30 million people
worldwide by 2040 and is highly prevalent in the Asian population. PACG is more severe …
worldwide by 2040 and is highly prevalent in the Asian population. PACG is more severe …
[HTML][HTML] Class I HDAC inhibitors enhance antitumor efficacy and persistence of CAR-T cells by activation of the Wnt pathway
M Zhu, Y Han, T Gu, R Wang, X Si, D Kong, P Zhao… - Cell Reports, 2024 - cell.com
Epigenetic modification shapes differentiation trajectory and regulates the exhaustion state
of chimeric antigen receptor T (CAR-T) cells. Limited efficacy induced by terminal exhaustion …
of chimeric antigen receptor T (CAR-T) cells. Limited efficacy induced by terminal exhaustion …
[HTML][HTML] GLIS1 regulates trabecular meshwork function and intraocular pressure and is associated with glaucoma in humans
KS Nair, C Srivastava, RV Brown, S Koli… - Nature …, 2021 - nature.com
Chronically elevated intraocular pressure (IOP) is the major risk factor of primary open-angle
glaucoma, a leading cause of blindness. Dysfunction of the trabecular meshwork (TM) …
glaucoma, a leading cause of blindness. Dysfunction of the trabecular meshwork (TM) …
SiNiSan alleviates liver injury by promoting hepatic stem cell differentiation via Wnt/β-catenin signaling pathway
W Xu, X Du, J Li, Z Zhang, X Ma, D Luo, M Xiao, Q Sun - Phytomedicine, 2022 - Elsevier
Abstract Background SiNiSan, a Traditional Chinese Medicine containing Radix Bupleuri,
Radix Paeoniae Alba, Fructus Aurantii Immaturus, and Radix Glycyrrhizae, has been shown …
Radix Paeoniae Alba, Fructus Aurantii Immaturus, and Radix Glycyrrhizae, has been shown …
[HTML][HTML] A circular RNA derived from GLIS3 accelerates the proliferation of glioblastoma cells through competitively binding with miR-449c-5p to upregulate CAPG and …
Q Zhou, M Shaya, Y Kugeluke, Q Fu, S Li… - BMC neuroscience, 2022 - Springer
Background Glioblastoma (GBM) is an aggressive and malignant brain tumor with extremely
poor prognosis. Despite advances in treatment, the pathogenesis of GBM remains elusive …
poor prognosis. Despite advances in treatment, the pathogenesis of GBM remains elusive …
Emerging roles of GLI-similar Krüppel-like zinc finger transcription factors in leukemia and other cancers
AM Jetten - Trends in cancer, 2019 - cell.com
GLI-similar 1–3 (GLIS1–3), a subfamily of Krüppel-like zinc finger transcription factors,
function as key regulators of several biological processes important to oncogenesis …
function as key regulators of several biological processes important to oncogenesis …
[HTML][HTML] GLIS1-3: links to primary cilium, reprogramming, stem cell renewal, and disease
AM Jetten, DW Scoville, HS Kang - Cells, 2022 - mdpi.com
The GLI-Similar 1-3 (GLIS1-3) genes, in addition to encoding GLIS1-3 Krüppel-like zinc
finger transcription factors, also generate circular GLIS (circGLIS) RNAs. GLIS1-3 regulate …
finger transcription factors, also generate circular GLIS (circGLIS) RNAs. GLIS1-3 regulate …
[HTML][HTML] GLIS3 regulates transcription of thyroid hormone biosynthetic genes in coordination with other thyroid transcription factors
HS Kang, SA Grimm, R Jothi, P Santisteban, AM Jetten - Cell & Bioscience, 2023 - Springer
Background Loss of the transcription factor GLI-Similar 3 (GLIS3) function causes congenital
hypothyroidism (CH) in both humans and mice due to decreased expression of several …
hypothyroidism (CH) in both humans and mice due to decreased expression of several …
[HTML][HTML] GLIS3 expression in the thyroid gland in relation to TSH signaling and regulation of gene expression
HS Kang, SA Grimm, XH Liao, AM Jetten - Cellular and Molecular Life …, 2024 - Springer
Abstract Loss of GLI-Similar 3 (GLIS3) function in mice and humans causes congenital
hypothyroidism (CH). In this study, we demonstrate that GLIS3 protein is first detectable at …
hypothyroidism (CH). In this study, we demonstrate that GLIS3 protein is first detectable at …