COVID-19 in children: where do we stand?

GB Nikolopoulou, HC Maltezou - Archives of medical research, 2022 - Elsevier
From the beginning of the coronavirus disease 2019 (COVID-19) pandemic it became
evident that children infected with the severe acute respiratory syndrome coronavirus 2 …

Defining trained immunity and its role in health and disease

MG Netea, J Domínguez-Andrés, LB Barreiro… - Nature Reviews …, 2020 - nature.com
Immune memory is a defining feature of the acquired immune system, but activation of the
innate immune system can also result in enhanced responsiveness to subsequent triggers …

[HTML][HTML] SARS-CoV-2-derived peptides define heterologous and COVID-19-induced T cell recognition

A Nelde, T Bilich, JS Heitmann, Y Maringer… - Nature …, 2021 - nature.com
T cell immunity is central for the control of viral infections. To characterize T cell immunity,
but also for the development of vaccines, identification of exact viral T cell epitopes is …

Trained immunity: a tool for reducing susceptibility to and the severity of SARS-CoV-2 infection

MG Netea, EJ Giamarellos-Bourboulis… - Cell, 2020 - cell.com
SARS-CoV-2 infection is mild in the majority of individuals but progresses into severe
pneumonia in a small proportion of patients. The increased susceptibility to severe disease …

Trained immunity: adaptation within innate immune mechanisms

J Domínguez-Andrés, JC Dos Santos… - Physiological …, 2023 - journals.physiology.org
The mechanisms underlying innate immune memory have been extensively explored in the
last decades but are in fact largely unknown. Although the specificity of adaptive immune …

BCG vaccination in humans elicits trained immunity via the hematopoietic progenitor compartment

B Cirovic, LCJ de Bree, L Groh, BA Blok, J Chan… - Cell host & …, 2020 - cell.com
Induction of trained immunity by Bacille-Calmette-Guérin (BCG) vaccination mediates
beneficial heterologous effects, but the mechanisms underlying its persistence and …

Innate and adaptive immune memory: an evolutionary continuum in the host's response to pathogens

MG Netea, A Schlitzer, K Placek, LAB Joosten… - Cell host & …, 2019 - cell.com
Immunological memory is an important evolutionary trait that improves host survival upon
reinfection. Memory is a characteristic recognized within both the innate and adaptive arms …

[HTML][HTML] Innate-adaptive immunity interplay and redox regulation in immune response

L Sun, X Wang, J Saredy, Z Yuan, X Yang, H Wang - Redox biology, 2020 - Elsevier
Innate and adaptive immune cell activation and infiltration is the key characteristic of tissue
inflammation. The innate immune system is the front line of host defense in which innate …

[HTML][HTML] Immune defence to invasive fungal infections: A comprehensive review

B Pathakumari, G Liang, W Liu - Biomedicine & Pharmacotherapy, 2020 - Elsevier
The fungal infections are relatively common in humans that can range from common, mild
superficial infections to life-threatening invasive infections. Most of the pathogenic fungi are …

Will children reveal their secret? The coronavirus dilemma

L Cristiani, E Mancino, L Matera… - European respiratory …, 2020 - Eur Respiratory Soc
On 11 March, 2020, a novel human coronavirus, named severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) became pandemic [1]. By 24 March, 372 757 SARS-CoV-2 …