Single-cell sequencing, including genomics, transcriptomics, epigenomics, proteomics and
metabolomics sequencing, is a powerful tool to decipher the cellular and molecular …

Mitochondria are not only the main energy supplier but are also the cell metabolic center
regulating multiple key metaborates that play pivotal roles in epigenetics regulation. These …

Reversible, spatial, and temporal regulation of metabolic reprogramming and epigenetic
homeostasis are prominent hallmarks of carcinogenesis. Cancer cells reprogram their …

RNA methylations, as the prevalent post-transcriptional modifications, are critical in
regulating various biological processes, such as RNA transcription, splicing, structure …

DNA methylation, ie, addition of methyl group to 5′-carbon of cytosine residues in CpG
dinucleotides, is an important epigenetic modification regulating gene expression, and thus …

Abstract Analysis of DNA methylation is a valuable tool to understand disease progression
and is increasingly being used to create diagnostic and prognostic clinical biomarkers …

Melatonin is an important naturally occurring hormone in mammals. Melatonin-mediated
biological effects include the regulation of circadian rhythms, which is important for optimal …

The study of the metastatic cascade has revealed the complexity of the process and the
multiple cellular states that disseminated cancer cells must go through. The tumor …

It is known that estrogen stimulates growth and inhibits apoptosis through estrogen receptor
(ER)-mediated mechanisms in many cancer cell types. Interestingly, there is strong evidence …

Next generation sequencing (NGS) has provided biologists with an unprecedented view into
biological processes and their regulation over the past 2 decades, fueling a wave of …