[HTML][HTML] Impact of gastrointestinal tract variability on oral drug absorption and pharmacokinetics: An UNGAP review
The absorption of oral drugs is frequently plagued by significant variability with potentially
serious therapeutic consequences. The source of variability can be traced back to …
serious therapeutic consequences. The source of variability can be traced back to …
Developmental changes in pharmacokinetics and pharmacodynamics
Effective drug therapy to optimally influence disease requires an understanding of a drug's
pharmacokinetic, pharmacodynamic, and pharmacogenomic interrelationships. In …
pharmacokinetic, pharmacodynamic, and pharmacogenomic interrelationships. In …
[HTML][HTML] Impact of gastrointestinal physiology on drug absorption in special populations––An UNGAP review
C Stillhart, K Vučićević, P Augustijns, AW Basit… - European Journal of …, 2020 - Elsevier
The release and absorption profile of an oral medication is influenced by the
physicochemical properties of the drug and its formulation, as well as by the anatomy and …
physicochemical properties of the drug and its formulation, as well as by the anatomy and …
[HTML][HTML] Physiologically-based pharmacokinetic models for children: Starting to reach maturation?
LFM Verscheijden, JB Koenderink, TN Johnson… - Pharmacology & …, 2020 - Elsevier
Developmental changes in children can affect the disposition and clinical effects of a drug,
indicating that scaling an adult dose simply down per linear weight can potentially lead to …
indicating that scaling an adult dose simply down per linear weight can potentially lead to …
[HTML][HTML] Potential applications of chitosan-based nanomaterials to surpass the gastrointestinal physiological obstacles and enhance the intestinal drug absorption
N Pathomthongtaweechai, C Muanprasat - Pharmaceutics, 2021 - mdpi.com
The small intestine provides the major site for the absorption of numerous orally
administered drugs. However, before reaching to the systemic circulation to exert beneficial …
administered drugs. However, before reaching to the systemic circulation to exert beneficial …
Preterm physiologically based pharmacokinetic model. Part II: applications of the model to predict drug pharmacokinetics in the preterm population
K Abduljalil, X Pan, A Pansari, M Jamei… - Clinical …, 2020 - Springer
Background Preterm neonates are usually not part of a traditional drug development
programme, however they are frequently administered medicines. Developing modelling …
programme, however they are frequently administered medicines. Developing modelling …
[HTML][HTML] The blind spot of pharmacology: a scoping review of drug metabolism in prematurely born children
ML Mørk, JT Andersen, U Lausten-Thomsen… - Frontiers in …, 2022 - frontiersin.org
The limit for possible survival after extremely preterm birth has steadily improved and
consequently, more premature neonates with increasingly lower gestational age at birth now …
consequently, more premature neonates with increasingly lower gestational age at birth now …
[HTML][HTML] Quantification of drug metabolising enzymes and transporter proteins in the paediatric duodenum via LC-MS/MS proteomics using a QconCAT technique
J Goelen, G Farrell, J McGeehan, CM Titman… - European Journal of …, 2023 - Elsevier
Characterising the small intestine absorptive membrane is essential to enable prediction of
the systemic exposure of oral formulations. In particular, the ontogeny of key intestinal Drug …
the systemic exposure of oral formulations. In particular, the ontogeny of key intestinal Drug …
Considerations for drug dosing in premature infants
J van den Anker, K Allegaert - The Journal of Clinical …, 2021 - Wiley Online Library
In premature infants, effective and safe drug therapy depends on optimal dose selection and
requires a thorough understanding of the underlying disease (s) of these fragile infants as …
requires a thorough understanding of the underlying disease (s) of these fragile infants as …
Anatomical distribution and expression of CYP in humans: Neuropharmacological implications
D Fanni, F Pinna, C Gerosa, P Paribello… - Drug Development …, 2021 - Wiley Online Library
Abstract The cytochrome P450 (CYP450) superfamily is responsible for the metabolism of
most xenobiotics and pharmacological treatments generally used in clinical settings. Genetic …
most xenobiotics and pharmacological treatments generally used in clinical settings. Genetic …