Altered glucose metabolism in Alzheimer's disease: role of mitochondrial dysfunction and oxidative stress

S Dewanjee, P Chakraborty, H Bhattacharya… - Free Radical Biology …, 2022 - Elsevier
Increasing evidence suggests that abnormal cerebral glucose metabolism is largely present
in Alzheimer's disease (AD). The brain utilizes glucose as its main energy source and a …

Polyphenols: Immunonutrients tipping the balance of immunometabolism in chronic diseases

C Ferreira, P Vieira, H Sá, J Malva… - Frontiers in …, 2024 - frontiersin.org
Mounting evidence progressively appreciates the vital interplay between immunity and
metabolism in a wide array of immunometabolic chronic disorders, both autoimmune and …

Understanding the pivotal role of the vagus nerve in Health from pandemics

CM Rangon, A Niezgoda - Bioengineering, 2022 - mdpi.com
The COVID-19 pandemic seems endless with the regular emergence of new variants. Is the
SARS-CoV-2 virus particularly evasive to the immune system, or is it merely disrupting …

Neuroprotective Effects of Zerumbone on H2O2-Induced Oxidative Injury in Human Neuroblastoma SH-SY5Y Cells

HR Moon, JM Yun - Journal of Medicinal Food, 2023 - liebertpub.com
Oxidative stress is recognized as one of the main reasons for cellular damage and
neurodegenerative diseases. Zerumbone is one of the sesquiterpenoid compounds in the …

Metabolic characterization of neurogenetic disorders involving glutamatergic neurotransmission

S Illescas, Y Diaz‐Osorio, A Serradell… - Journal of Inherited …, 2024 - Wiley Online Library
The study of inborn errors of neurotransmission has been mostly focused on monoamine
disorders, GABAergic and glycinergic defects. The study of the glutamatergic synapse using …

Metabolic Reprogramming toward Aerobic Glycolysis and the Gut Microbiota Involved in the Brain Amyloid Pathology

T Murai, S Matsuda - Biology, 2023 - mdpi.com
Simple Summary Amyloid-β toxicity is attributed to oligomer and fibrillar amyloid-β, which
either damages the neurons or initiates an intracellular signaling cascade toward neuronal …

Ferroptosis: A novel therapeutic strategy and mechanism of action in glioma

G Zhang, Y Fang, X Li, Z Zhang - Frontiers in oncology, 2022 - frontiersin.org
Glioma is the most common malignant tumor of the central nervous system and resistance is
easily developed to chemotherapy drugs during the treatment process, resulting in high …

Microglial immunometabolism endophenotypes contribute to sex difference in Alzheimer's disease

Y Hou, JZK Caldwell, JD Lathia… - Alzheimer's & …, 2024 - Wiley Online Library
INTRODUCTION The molecular mechanisms that contribute to sex differences, in particular
female predominance, in Alzheimer's disease (AD) prevalence, symptomology, and …

Bridging metabolic syndrome and cognitive dysfunction: role of astrocytes

Z Li, Y Jiang, C Long, X Peng, J Tao, Y Pu… - Frontiers in …, 2024 - frontiersin.org
Metabolic syndrome (MetS) and cognitive dysfunction pose significant challenges to global
health and the economy. Systemic inflammation, endocrine disruption, and autoregulatory …

Metabolic reprogramming of the inflammatory response in the nervous system: the crossover between inflammation and metabolism

J Amo-Aparicio, CA Dinarello… - Neural Regeneration …, 2024 - journals.lww.com
Metabolism is a fundamental process by which biochemicals are broken down to produce
energy (catabolism) or used to build macromolecules (anabolism). Metabolism has received …