Comprehensive review of uterine fibroids: developmental origin, pathogenesis, and treatment

Q Yang, M Ciebiera, MV Bariani, M Ali… - Endocrine …, 2022 - academic.oup.com
Uterine fibroids are benign monoclonal neoplasms of the myometrium, representing the
most common tumors in women worldwide. To date, no long-term or noninvasive treatment …

Short chain fatty acid metabolism in relation to gut microbiota and genetic variability

G Ramos Meyers, H Samouda, T Bohn - Nutrients, 2022 - mdpi.com
It is widely accepted that the gut microbiota plays a significant role in modulating
inflammatory and immune responses of their host. In recent years, the host-microbiota …

Assessment of corneal substrate biomechanics and its effect on epithelial stem cell maintenance and differentiation

RM Gouveia, G Lepert, S Gupta, RR Mohan… - Nature …, 2019 - nature.com
Whilst demonstrated extensively in vitro, the control of cell behaviour via modulation of
substrate compliance in live tissues has not been accomplished to date. Here we propose …

[HTML][HTML] Therapeutic applications of collagenase (metalloproteases): A review

H Alipour, A Raz, S Zakeri, ND Djadid - Asian Pacific Journal of Tropical …, 2016 - Elsevier
Non-invasive therapeutic methods have recently been used in medical sciences. Enzymes
have shown high activity at very low concentrations in laboratories and pharmaceutical …

Dynamic reciprocity between cells and their microenvironment in reproduction

JT Thorne, TR Segal, S Chang, S Jorge… - Biology of …, 2015 - academic.oup.com
Dynamic reciprocity (DR) refers to the ongoing, bidirectional interaction between cells and
their microenvironment, specifically the extracellular matrix (ECM). The continuous …

Extracellular matrix and Hippo signaling as therapeutic targets of antifibrotic compounds for uterine fibroids

MS Islam, S Afrin, B Singh, FL Jayes… - Clinical and …, 2021 - Wiley Online Library
Background Uterine fibroids are highly prevalent, collagen‐rich, mechanically stiff, fibrotic
tumors for which new therapeutic options are needed. Increased extracellular matrix (ECM) …

Evidence of biomechanical and collagen heterogeneity in uterine fibroids

FL Jayes, B Liu, L Feng, N Aviles-Espinoza, S Leikin… - PLoS …, 2019 - journals.plos.org
Objective Uterine fibroids (leiomyomas) are common benign tumors of the myometrium but
their molecular pathobiology remains elusive. These stiff and often large tumors contain …

The evolving role of natural compounds in the medical treatment of uterine fibroids

M Ciebiera, M Ali, L Prince, T Jackson-Bey… - Journal of clinical …, 2020 - mdpi.com
Uterine fibroids (UFs) remain a significant health issue for many women, with a
disproportionate impact on women of color, likely due to both genetic and environmental …

Evidence-based approach for secondary prevention of uterine fibroids (The ESCAPE approach)

S Vafaei, M Ciebiera, MM Omran… - International Journal of …, 2023 - mdpi.com
Uterine fibroids (UFs) are common tumors in women of reproductive age. It is imperative to
comprehend UFs' associated risk factors to facilitate early detection and prevention. Simple …

[HTML][HTML] Prevention of uterine fibroids: Molecular mechanisms and potential clinical application

M Ali, MV Bariani, S Vafaei, MM Omran, Q Yang… - Journal of endometriosis …, 2023 - Elsevier
Uterine fibroids (UFs; leiomyoma) are the most common benign neoplastic threat to women
worldwide, exacting an immense personal burden on female health and a monetary …