Liver transplantation for intrahepatic cholangiocarcinoma: ready for prime time?

G Sapisochin, T Ivanics, J Heimbach - Hepatology, 2022 - Wiley Online Library
Cholangiocarcinoma (CCA) represents the second‐most common primary liver malignancy
after HCC and has risen in incidence globally in the past decades. Intrahepatic …

[HTML][HTML] Mechanistic insight and clinical implications of ischemia/reperfusion injury post liver transplantation

J Liu, K Man - Cellular and molecular gastroenterology and …, 2023 - Elsevier
Ischemia/reperfusion injury is an inevitable process during liver transplantation and can lead
to a high incidence of early allograft dysfunction and graft failure. The mechanism of hepatic …

Liver transplantation for non-resectable colorectal liver metastases: the International Hepato-Pancreato-Biliary Association consensus guidelines

GK Bonney, CA Chew, P Lodge, J Hubbard… - The lancet …, 2021 - thelancet.com
Colorectal cancer is a prevalent disease worldwide, with more than 50% of patients
developing metastases to the liver. Despite advances in improving resectability, most …

[HTML][HTML] Ischaemia-free liver transplantation in humans: a first-in-human trial

Z Guo, Q Zhao, S Huang, C Huang, D Wang… - The Lancet Regional …, 2021 - thelancet.com
Background Ischaemia-reperfusion injury is considered an inevitable component of organ
transplantation, compromising organ quality and outcomes. Although several treatments …

[HTML][HTML] Exosomes derived from bone marrow mesenchymal stem cells alleviate biliary ischemia reperfusion injury in fatty liver transplantation by inhibiting ferroptosis

X Tian, L Wu, X Li, W Zheng, H Zuo, H Song - Molecular and Cellular …, 2024 - Springer
Fatty liver grafts are susceptible to ischemia reperfusion injury (IRI), increasing the risk of
biliary complications after liver transplantation (LT). Ferroptosis, a newly recognized …

[HTML][HTML] Dynamic impact of liver allocation policy change on donor utilization

E Chan, AJ Logan, JM Sneddon, N Singh… - American Journal of …, 2022 - Elsevier
Liver allocation policy was changed to reduce variance in median MELD scores at
transplant (MMaT) in February 2020.“Acuity circles” replaced local allocation. Understanding …

[HTML][HTML] Machine perfusion for extended criteria donor livers: what challenges remain?

J Widmer, J Eden, MF Carvalho, P Dutkowski… - Journal of Clinical …, 2022 - mdpi.com
Based on the renaissance of dynamic preservation techniques, extended criteria donor
(ECD) livers reclaimed a valuable eligibility in the transplantable organ pool. Being more …

US liver transplant outcomes after normothermic regional perfusion vs standard super rapid recovery

AL Brubaker, MT Sellers, PL Abt, KP Croome… - JAMA …, 2024 - jamanetwork.com
Importance Normothermic regional perfusion (NRP) is an emerging recovery modality for
transplantable allografts from controlled donation after circulatory death (cDCD) donors. In …

[HTML][HTML] Cold stress–induced ferroptosis in liver sinusoidal endothelial cells determines liver transplant injury and outcomes

H Kojima, H Hirao, K Kadono, T Ito, S Yao… - JCI insight, 2024 - ncbi.nlm.nih.gov
Although cold preservation remains the gold standard in organ transplantation, cold stress–
induced cellular injury is a significant problem in clinical orthotopic liver transplantation …

Deficiency of neutrophil high-mobility group box-1 in liver transplant recipients exacerbates early allograft injury in mice

Z Song, H Han, X Ge, S Das, R Desert, D Athavale… - Hepatology, 2023 - journals.lww.com
Deficiency of neutrophil high-mobility group box-1 in liver... : Hepatology Deficiency of neutrophil
high-mobility group box-1 in liver transplant recipients exacerbates early allograft injury in mice …