Cell death is a fundamental physiological process in all living organisms. Its roles extend
from embryonic development, organ maintenance, and aging to the coordination of immune …

Abstract The NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome is
a multiprotein complex involved in the release of mature interleukin-1β and triggering of …

Cell death is an essential process in all living organisms and occurs through different
mechanisms. The three main types of programmed cell death are apoptosis, pyroptosis, and …

Inflammasomes are large cytosolic multiprotein complexes assembled in response to
infection and cellular stress, and are crucial for the activation of inflammatory caspases and …

Nucleotide-binding oligomerization domain-like receptor family pyrin domain containing 3
(NLRP3) is an intracellular innate immune receptor that recognizes a diverse range of …

Cellular inflammasome activation causes caspase-1 cleavage of the pore-forming protein
gasdermin D (GSDMD) with subsequent pyroptotic cell death and cytokine release. Here …

Mitochondria are cellular organelles with a major role in many cellular processes, including
not only energy production, metabolism, and calcium homeostasis but also regulated cell …

Caspase-8 is an apical caspase involved in the programmed form of cell death called
apoptosis that is critically important for mammalian development and immunity. Apoptosis …

ATP and its receptor P2RX7 exert a pivotal effect on antitumor immunity during
chemotherapy-induced immunogenic cell death (ICD). Here, we demonstrated that TNFα …

Sepsis, a life-threatening organ dysfunction caused by a dysregulated host response to
infection, is a leading cause of death in intensive care units. The development of sepsis …