Oxidative stress in alzheimer's disease: A review on emergent natural polyphenolic therapeutics

L Cassidy, F Fernandez, JB Johnson, M Naiker… - … therapies in medicine, 2020 - Elsevier
Objectives The aim of this research was to review the literature on Alzheimer's disease (AD)
with a focus on polyphenolics as antioxidant therapeutics. Design This review included a …

Neuroprotection by the metabolic antioxidant α-lipoic acid

L Packer, HJ Tritschler, K Wessel - Free radical biology and medicine, 1997 - Elsevier
Reactive oxygen species are thought to be involved in a number of types of acute and
chronic pathologic conditions in the brain and neural tissue. The metabolic antioxidant α …

Frequency of stages of Alzheimer-related lesions in different age categories

H Braak, E Braak - Neurobiology of aging, 1997 - Elsevier
Alzheimer's disease is a relentlessly progressing dementing disorder. Major pathological
hallmarks include extracellular deposits of amyloid protein and intraneuronal neurofibrillary …

[HTML][HTML] Traditional Chinese medicine: role in reducing β-amyloid, apoptosis, autophagy, neuroinflammation, oxidative stress, and mitochondrial dysfunction of …

SY Chen, Y Gao, JY Sun, XL Meng, D Yang… - Frontiers in …, 2020 - frontiersin.org
Alzheimer's disease (AD) is a progressive age-related neurodegenerative disease
characterized by memory loss and cognitive impairment. The major characteristics of AD are …

Silibinin ameliorates formaldehyde‐induced cognitive impairment by inhibiting oxidative stress

P Wei, X Li, S Wang, Y Dong, H Yin… - Oxidative Medicine …, 2022 - Wiley Online Library
Silibinin is a flavonoid extracted from the medicinal plant Silybum marianum (milk thistle),
traditionally used to treat liver disease. Recent studies have shown that the antioxidative …

Amyloid β Peptide–Induced Cerebral Endothelial Cell Death Involves Mitochondrial Dysfunction and Caspase Activation

J Xu, S Chen, G Ku, SH Ahmed, J Xu… - Journal of Cerebral …, 2001 - journals.sagepub.com
Amyloid β peptide (Aβ), a 39 to 43 amino acid fragment of the β-amyloid precursor protein
(βAPP), forms insoluble fibrillar accumulation in neurofibrillary tangles and vascular …

Xanthine oxidase activity in vitro: effects of food extracts and components

TP Dew, AJ Day, MRA Morgan - Journal of Agricultural and Food …, 2005 - ACS Publications
There is significant interest in the direct antioxidant activities of dietary polyphenols, due to
associations between consumption of polyphenol-rich foods, such as fruits and vegetables …

Explore the effects of Huang-Lian-Jie-Du-Tang on Alzheimer's disease by UPLC-QTOF/MS-based plasma metabolomics study

LM Sun, BJ Zhu, HT Cao, XY Zhang, QC Zhang… - … of pharmaceutical and …, 2018 - Elsevier
Alzheimer's disease (AD) is a progressive neurodegenerative disease with neither definitive
pathogenesis nor effective treatment method so far. Huang-Lian-Jie-Du-Tang (HLJDT) is a …

Vitamin E levels, cognitive impairment and dementia in older persons: the InCHIANTI study

A Cherubini, A Martin, C Andres-Lacueva, A Di Iorio… - Neurobiology of …, 2005 - Elsevier
There is conflicting evidence that antioxidants contribute to maintaining cognitive function in
elderly subjects. We investigated whether vitamin E plasma levels are related to the …

Binding of amyloid β‐peptide to mitochondrial hydroxyacyl‐CoA dehydrogenase (ERAB): regulation of an SDR enzyme activity with implications for apoptosis in …

UCT Oppermann, S Salim, LO Tjernberg… - FEBS …, 1999 - Wiley Online Library
The intracellular amyloid β‐peptide (Aβ) binding protein, ERAB, a member of the short‐
chain dehydrogenase/reductase (SDR) family, is known to mediate apoptosis in different cell …