Enzymes of glutathione metabolism, particularly gamma-glutamyltransferase (GGT) and
glutathione S-transferase (GST), play a role in multistage hepatocarcinogenesis. The …

Inactivation of the p16 INK4a (p16) tumor suppressor gene by promoter hypermethylation
and mutation within exon 3 of β-catenin represent two of the more common gene alterations …

Possible tumor‐promoting activity of four flavonoids, quercetin (QC), tangeretin (TG), flavone
(FO), and flavanone (FN), was examined in a rat liver short‐term carcinogenesis assay as …

Six halogenated hydrocarbons, chloroform, 1, 2-dibromoethane (1, 2-DBE), 1, 1-
dichloroethane (1, 1-DCE), 1, 2-dichloroethane (1, 2-DCE), 1, 1, 1-trichloroethane (1, 1, 1 …

To extend our ongoing characterization of modulatory influences on hepatic tumorigenesis,
we examined effects of rat strain (Sprague-Dawley versus Fischer), diet composition …

The level and type of dietary protein has been shown to markedly affect the development of
chemically-induced and spontaneous preneoplastic and neoplastic lesions. These studies …

The effects of feeding high protein diets that promote the development of aflatoxin B 1 (AFB
1)-induced gamma-glutamyl transpeptidase positive (GGT+) preneoplastic lesions were …

When treated with phorbol tumor promoters, HL-60 cells undergo terminal differentiation
evidenced by a transition from a non-phagocytic suspension culture to an attached fibroblast …

The study of chemical-induced hepatocarcinogenesis has provided strong insight into the
tumor formation process. A variety of chemicals and agents can increase the incidence …

Significant numbers of chemicals have been shown to be carcinogenic in mouse liver
although they do not exhibit carcinogenic activity in other organs or tissues of mice or rats …