Unlocking the potential of TRPV1 based siRNA therapeutics for the treatment of chemotherapy-induced neuropathic pain
Chemotherapy-induced neuropathic pain (CINP) is among the most common clinical
complications associated with the use of anti-cancer drugs. CINP occurs in nearly 68.1% of …
complications associated with the use of anti-cancer drugs. CINP occurs in nearly 68.1% of …
Dietary interventions are beneficial for patients with chronic pain: a systematic review with meta-analysis
R Field, F Pourkazemi, J Turton, K Rooney - Pain Medicine, 2021 - academic.oup.com
Abstract Background The standard Western diet is high in processed hyperpalatable foods
that displace nutrient-dense whole foods, leading to inflammation and oxidative stress …
that displace nutrient-dense whole foods, leading to inflammation and oxidative stress …
Dietary alteration of n-3 and n-6 fatty acids for headache reduction in adults with migraine: Randomized controlled trial
CE Ramsden, D Zamora, KR Faurot, B MacIntosh… - bmj, 2021 - bmj.com
Objective To determine whether dietary interventions that increase n-3 fatty acids with and
without reduction in n-6 linoleic acid can alter circulating lipid mediators implicated in …
without reduction in n-6 linoleic acid can alter circulating lipid mediators implicated in …
Lipid oxidation that is, and is not, inhibited by vitamin E: Consideration about physiological functions of vitamin E
E Niki - Free Radical Biology and Medicine, 2021 - Elsevier
Lipids are oxidized in vivo by multiple oxidizing species with different properties, some by
regulated manner to produce physiological mediators, while others by random mechanisms …
regulated manner to produce physiological mediators, while others by random mechanisms …
Fecal transplantation and butyrate improve neuropathic pain, modify immune cell profile, and gene expression in the PNS of obese mice
RR Bonomo, TM Cook, CK Gavini… - Proceedings of the …, 2020 - National Acad Sciences
Obesity affects over 2 billion people worldwide and is accompanied by peripheral
neuropathy (PN) and an associated poorer quality of life. Despite high prevalence, the …
neuropathy (PN) and an associated poorer quality of life. Despite high prevalence, the …
Biofilm-derived oxylipin 10-HOME–mediated immune response in women with breast implants
This study investigates a mechanistic link of bacterial biofilm–mediated host-pathogen
interaction leading to immunological complications associated with breast implant illness …
interaction leading to immunological complications associated with breast implant illness …
Iron metabolism and ferroptosis in peripheral nerve injury
L Huang, M Bian, J Zhang… - Oxidative Medicine and …, 2022 - Wiley Online Library
Peripheral nerve injury (PNI) is a major clinical problem that may lead to different levels of
sensory and motor dysfunction including paralysis. Due to the high disability rate and …
sensory and motor dysfunction including paralysis. Due to the high disability rate and …
Drug repurposing to target neuroinflammation and sensory neuron-dependent pain
M Sisignano, P Gribbon, G Geisslinger - Drugs, 2022 - Springer
Around 20% of the American population have chronic pain and estimates in other Western
countries report similar numbers. This represents a major challenge for global health care …
countries report similar numbers. This represents a major challenge for global health care …
Early evidence of efficacy for orally administered SPM-enriched marine lipid fraction on quality of life and pain in a sample of adults with chronic pain
N Callan, D Hanes, R Bradley - Journal of translational medicine, 2020 - Springer
Background Marine lipids contain omega-3 fatty acids that can be metabolized into anti-
inflammatory and pro-resolving mediators—namely 17-HDHA and 18-HEPE—which can …
inflammatory and pro-resolving mediators—namely 17-HDHA and 18-HEPE—which can …
Long COVID and the neuroendocrinology of microbial translocation outside the GI tract: some treatment strategies
A Sfera, C Osorio, S Hazan, Z Kozlakidis… - Endocrines, 2022 - mdpi.com
Similar to previous pandemics, COVID-19 has been succeeded by well-documented post-
infectious sequelae, including chronic fatigue, cough, shortness of breath, myalgia, and …
infectious sequelae, including chronic fatigue, cough, shortness of breath, myalgia, and …