Regulatory T (Treg) cells represent a distinct lineage of cells of the adaptive immune system
indispensable for forestalling fatal autoimmune and inflammatory pathologies. The role of …

Germinal center (GC) B cells are the source of the high-affinity, class-switched antibodies
required for protective immunity. The unique biology of GC B cells involves iterative rounds …

We previously demonstrated that tumor-infiltrating lymphocytes (TIL) in human breast cancer
sometimes form organized tertiary lymphoid structures (TLS) characterized by CXCL13 …

The identification of CD4+ T cells localizing to B cell follicles has revolutionized the
knowledge of how humoral immunity is generated. Follicular helper T (TFH) cells support …

Immunosuppressive regulatory T cells (Tregs) provide a main mechanism of tumor immune
evasion. Targeting Tregs, especially in the tumor microenvironment (TME), continues to be …

Coronavirus disease 2019 (COVID-19), caused by the novel severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), is a serious infectious disease that has led to a …

Altered composition of gut bacteria and changes to the production of their bioactive
metabolites, the short-chain fatty acids (SCFAs), have been implicated in the development of …

Follicular helper T (Tfh) cells promote, whereas follicular regulatory T (Tfr) cells restrain,
germinal center (GC) reactions. However, the precise roles of these cells in the complex GC …

The integrin lymphocyte function–associated antigen 1 (LFA-1) helps to coordinate the
migration, adhesion, and activation of T cells through interactions with intercellular adhesion …

Regulatory T cells (Tregs) are essential to control immune system responses to innocuous
self-specificities, intestinal and environmental antigens. However, they may also interfere …