Managing hyperlipidaemia in patients with COVID-19 and during its pandemic: An expert panel position statement from HEART UK

Z Iqbal, JH Ho, S Adam, M France, A Syed, D Neely… - Atherosclerosis, 2020 - Elsevier
The emergence of the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-
2) which causes Coronavirus Disease 2019 (COVID-19) has resulted in a pandemic. SARS …

Molecular targets of statins and their potential side effects: Not all the glitter is gold

KK Patel, VS Sehgal, K Kashfi - European journal of pharmacology, 2022 - Elsevier
Statins are a class of drugs widely used worldwide to manage hypercholesterolemia and the
prevention of secondary heart attacks. Currently, available statins vary in terms of their …

Flavonoid-statin interactions causing myopathy and the possible significance of OATP transport, CYP450 metabolism and mevalonate synthesis

J Zechner, SM Britza, R Farrington, RW Byard… - Life Sciences, 2022 - Elsevier
hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase inhibitors, statins, are a
primary treatment for hyperlipidemic cardiovascular diseases which are a leading global …

Detection of statin-induced rhabdomyolysis and muscular related adverse events through data mining technique

P Kunakorntham, O Pattanaprateep… - BMC Medical Informatics …, 2022 - Springer
Background and objective Rhabdomyolysis (RM) is a life-threatening adverse drug reaction
in which statins are the one commonly related to RM. The study aimed to explore the …

Bile acid/fatty acid integrated nanoemulsomes for nonalcoholic fatty liver targeted lovastatin delivery; stability, in-vitro, ex-vivo, and in-vivo analyses

SA Faran, T Hussain, SH Khalid, IU Khan… - Expert Opinion on …, 2024 - Taylor & Francis
Background Controlled and targeted drug delivery to treat nonalcoholic fatty liver disease
(NAFLD) can benefit from additive attributes of natural formulation ingredients incorporated …

Safety and tolerability of antimicrobial agents in the older patient

L Soraci, A Cherubini, L Paoletti, G Filippelli, F Luciani… - Drugs & Aging, 2023 - Springer
Older patients are at high risk of infections, which often present atypically and are associated
with high morbidity and mortality. Antimicrobial treatment in older individuals with infectious …

Influence of Tyrosine Kinase Inhibition on Organic Anion Transporting Polypeptide 1B3-Mediated Uptake

VN Hove, K Anderson, ER Hayden… - Molecular …, 2022 - ASPET
The organic anion transporting polypeptide family member (OATP) 1B3 is a hepatic uptake
transporter that has a broad substrate recognition and plays a significant role in regulating …

Colchicine use and risks of stroke recurrence in acute non-cardiogenic ischemic stroke patients: a population-based cohort study

CH Liu, YS Lin, PS Sung, YC Wei, TY Chang… - Journal of personalized …, 2021 - mdpi.com
Background: The objective is to study whether the cardiovascular protective effects of
colchicines could be applied to non-cardiogenic ischemic stroke (IS) patients. Patients and …

Antibiotics and Lipid-Modifying Agents: Potential Drug–Drug Interactions and Their Clinical Implications

M Spanakis, D Alon-Ellenbogen, P Ioannou… - Pharmacy, 2023 - mdpi.com
Evidence-based prescribing requires taking into consideration the many aspects of optimal
drug administration (eg, dosage, comorbidities, co-administered drugs, etc.). A key issue is …

Integrative proteomics and metabolomics approach to elucidate the antimicrobial effect of simvastatin on Escherichia coli

E Kocak, E Nemutlu, S Kır… - Biomedical …, 2021 - Wiley Online Library
Globally, simvastatin is one of the most commonly used statin drugs. Its antimicrobial
properties have been investigated against various pathogens. However, its effect on …