Inherited retinal diseases (IRDs) are a clinically complex and heterogenous group of visual
impairment phenotypes caused by pathogenic variants in at least 277 nuclear and …

Several recent studies in a number of model systems including zebrafish, Arabidopsis, and
mouse have revealed phenotypic differences between knockouts (ie, mutants) and …

A better understanding of the molecular mechanisms underlying disease is key for
expediting the development of novel therapeutic interventions. Disease mechanisms are …

Phenotypic characteristics of animals can change independently from changes in the
genetic code. These plastic phenotypic responses are important for population persistence …

Principles and Practice of Sleep Medicine, 5th Edition, by Meir H. Kryger, MD, FRCPC,
Thomas Roth, PhD, and William C. Dement, MD, PhD, delivers the comprehensive …

Epistasis, or interactions between genes, has long been recognized as fundamentally
important to understanding the structure and function of genetic pathways and the …

Abstract Charcot–Marie–Tooth disease and the related disorders hereditary motor
neuropathy and hereditary sensory neuropathy, collectively termed CMT, are the …

Genome-wide association studies (GWASs) have identified numerous loci that influence risk
for psychiatric diseases. Genetically engineered mice are often used to characterize genes …

A genetic interaction network containing∼ 1000 genes and∼ 4000 interactions was
mapped by crossing mutations in 132 different query genes into a set of∼ 4700 viable gene …

▪ Abstract Phenotypic variation for quantitative traits results from the segregation of alleles at
multiple quantitative trait loci (QTL) with effects that are sensitive to the genetic, sexual, and …