Citrullinating enzyme PADI4 and transcriptional repressor RING1B bind in cancer cells

S Araujo-Abad, B Rizzuti, L Soto-Conde, M Vidal… - International Journal of …, 2024 - Elsevier
Polycomb groups (PcGs) are transcriptional repressors, formed by a complex of several
proteins, involved in multicellular development and cancer epigenetics. One of these …

[HTML][HTML] Unveiling the Binding between the Armadillo-Repeat Domain of Plakophilin 1 and the Intrinsically Disordered Transcriptional Repressor RYBP

S Araujo-Abad, B Rizzuti, M Vidal, O Abian… - Biomolecules, 2024 - mdpi.com
Plakophilin 1 (PKP1), a member of the p120ctn subfamily of the armadillo (ARM)-repeat-
containing proteins, is an important structural component of cell–cell adhesion scaffolds …

Isolated auto-citrullinated regions of PADI4 associate to the intact protein without altering their disordered conformation

JL Neira, B Rizzuti, O Abian, A Velazquez-Campoy - Biophysical Chemistry, 2024 - Elsevier
PADI4 is one of the human isoforms of a group of enzymes intervening in the conversion of
arginine to citrulline. It is involved in the development of several types of tumors, as well as …