Targeting the JAK/STAT signaling pathway using phytocompounds for cancer prevention and therapy

S Bose, S Banerjee, A Mondal, U Chakraborty… - Cells, 2020 - mdpi.com
Cancer is a prevalent cause of mortality around the world. Aberrated activation of Janus
kinase (JAK)/signal transducer and activator of transcription (STAT) signaling pathway …

Plant flavonoids in cancer chemoprevention: role in genome stability

VC George, G Dellaire, HPV Rupasinghe - The Journal of nutritional …, 2017 - Elsevier
Carcinogenesis is a multistage process that involves a series of events comprising of
genetic and epigenetic changes leading to the initiation, promotion and progression of …

The potential health benefits of haskap (Lonicera caerulea L.): Role of cyanidin-3-O-glucoside

HPV Rupasinghe, N Arumuggam… - Journal of Functional …, 2018 - Elsevier
Abstract Haskap (Lonicera caerulea L.), an emerging commercial fruit crop in North America,
has been known for its medicinal benefits amongst the people of Russia, Japan, and …

The role of natural products as inhibitors of JAK/STAT signaling pathways in glioblastoma treatment

H Fahmideh, H Shapourian, R Moltafeti… - Oxidative medicine …, 2022 - Wiley Online Library
The permeability of glioblastoma, as well as its escaping the immune system, makes them
one of the most deadly human malignancies. By avoiding programmed cell death …

A review: phytochemicals targeting JAK/STAT signaling and IDO expression in cancer

N Arumuggam, NA Bhowmick… - Phytotherapy …, 2015 - Wiley Online Library
Cancer remains a major health problem worldwide. Among many other factors, two
regulatory defects that are present in most cancer cells are constitutive activation of Janus …

[图书][B] Aquatic dicotyledons of North America: ecology, life history, and systematics

DH Les - 2017 - taylorfrancis.com
Aquatic Dicotyledons of North America: Ecology, Life History, and Systematics brings
together a wealth of information on the natural history, ecology, and systematics of North …

Sugiol, a diterpenoid: Therapeutic actions and molecular pathways involved

VK Bajpai, S Sonwal, SK Hwang, S Shukla… - Pharmacological …, 2021 - Elsevier
Understanding how the natural products structural diversity interacts with cellular
metabolism and infectious disease targets remains a challenge. Inflammation is an …

Regulation of hypoxia-inducible factor-1α and vascular endothelial growth factor signaling by plant flavonoids

W Fernando, HP Vasantha Rupasinghe… - Mini Reviews in …, 2015 - ingentaconnect.com
Discovery of novel drugs that are able to prevent angiogenesis is a fast growing branch of
cancer research. Current approaches to cancer chemotherapy include the use of alkylating …

Growth inhibitory activity of biflavonoids and diterpenoids from the leaves of the Libyan Juniperus phoenicea against human cancer cells

A Al Groshi, HA Jasim, AR Evans… - Phytotherapy …, 2019 - Wiley Online Library
Three biflavonoids [cupressuflavone (1), amentoflavone (2), and sumaflavone (3)], four
diterpenoids [13‐epi‐cupressic acid (4), imbricatholic acid (5), 3‐hydroxy‐sandaracopimaric …

Docosahexaenoic acid-acylated phloridzin, a novel polyphenol fatty acid ester derivative, is cytotoxic to breast cancer cells

W Fernando, MRP Coombs, DW Hoskin… - …, 2016 - academic.oup.com
Docosahexaenoic acid-acylated phloridzin (PZ-DHA), a novel polyphenol fatty acid ester
derivative, was synthesized through a regioselective acylation reaction with the aim of …