Alzheimer disease (AD) is the most common form of dementia among the elderly and is
characterized by progressive loss of memory and cognition. Epidemiological data show that …

Neurodegenerative disorders are debilitating diseases of the brain, characterized by
behavioral, motor and cognitive impairments. Ample evidence underpins mitochondrial …

Current hypotheses and theories regarding the pathogenesis of Alzheimer's disease (AD)
heavily implicate brain insulin resistance (IR) as a key factor. Despite the many well …

Interventions that have even quite modest effects at the individual level could drastically
reduce the future burden of dementia associated with Alzheimer's disease at the population …

Insulin is now well-established as playing multiple roles within the brain, and specifically as
regulating hippocampal cognitive processes and metabolism. Impairments to insulin …

Obesity, metabolic syndrome, and type 2 diabetes (T2D) are related disorders with
widespread deleterious effects throughout the body. One important target of damage is the …

Overnutrition and modern diets containing high proportions of saturated fat are among the
major factors contributing to a low-grade state of inflammation, hyperglycemia and …

Alzheimer's disease (AD) is the most common form of dementia. It is characterized by beta-
amyloid (Aβ) peptide fibrils, which are extracellular depositions of a specific protein, and is …

During the past 5 decades, it has been widely promulgated that the chemicals in plants that
are good for health act as direct scavengers of free radicals. Here we review evidence that …

The links between systemic insulin resistance (IR), brain-specific IR, and Alzheimer's
disease (AD) have been an extremely productive area of current research. This review will …