In the design of delivery strategies for anticancer therapeutics, the controlled release of
intact cargo at the destined tumor and metastasis locations is of particular importance. To …

Inflammatory bowel disease (IBD) encompasses a set of chronic inflammatory conditions,
namely Crohn's disease and ulcerative colitis. Despite all advances in the management of …

High-fidelity preclinical in vitro tissue models can reduce the failure rate of drugs entering
clinical trials. Collagen and hyaluronic acid (HA) are major components of the extracellular …

Biofabricated in vitro models hold unrealized potential in accelerating drug discovery and
reducing new drug costs, but current models are overly simplified and lack physiological …

There is growing recognition that animal methods bias, a preference for animal‐based
methods where they are not necessary or where nonanimal‐based methods may already be …

Developing diagnostics and treatments for neurodegenerative diseases (NDs) is
challenging due to multifactorial pathogenesis that progresses gradually. Advanced in vitro …

On the 26 th January 2023, a free to attend,'improving in vivo snake venom research: a
community discussion'meeting was held virtually. This webinar brought together researchers …

Immunotherapies are a key therapeutic strategy to fight cancer. Diverse approaches are
used to activate tumor-directed immunity and to overcome tumor immune escape. The …

Thymic stromal lymphopoietin (TSLP) is a key player in atopic diseases, which has sparked
great interest in therapeutically targeting TSLP. Yet, no small-molecule TSLP inhibitors exist …

Microphysiological systems (MPS) are comprised of one or multiple cell types of human or
animal origins that mimic the biochemical/electrical/mechanical responses and blood-tissue …