Importance of the pig as a human biomedical model
JK Lunney, A Van Goor, KE Walker… - Science translational …, 2021 - science.org
Pigs have substantial potential as biomedical models for studying human developmental
processes, congenital diseases, and pathogen response mechanisms in addition to utility as …
processes, congenital diseases, and pathogen response mechanisms in addition to utility as …
Secondary osteoporosis
PR Ebeling, HH Nguyen, J Aleksova… - Endocrine …, 2022 - academic.oup.com
Osteoporosis is a global public health problem, with fractures contributing to significant
morbidity and mortality. Although postmenopausal osteoporosis is most common, up to 30 …
morbidity and mortality. Although postmenopausal osteoporosis is most common, up to 30 …
Pharmacologic improvement of CFTR function rapidly decreases sputum pathogen density, but lung infections generally persist
DP Nichols, SJ Morgan, M Skalland… - The Journal of …, 2023 - Am Soc Clin Investig
Background Lung infections are among the most consequential manifestations of cystic
fibrosis (CF) and are associated with reduced lung function and shortened survival. Drugs …
fibrosis (CF) and are associated with reduced lung function and shortened survival. Drugs …
Physiology and pathophysiology of human airway mucus
The mucus clearance system is the dominant mechanical host defense system of the human
lung. Mucus is cleared from the lung by cilia and airflow, including both two-phase gas-liquid …
lung. Mucus is cleared from the lung by cilia and airflow, including both two-phase gas-liquid …
CFTR-rich ionocytes mediate chloride absorption across airway epithelia
L Lei, S Traore, GSR Ibarra, PH Karp… - The Journal of …, 2023 - Am Soc Clin Investig
The volume and composition of a thin layer of liquid covering the airway surface defend the
lung from inhaled pathogens and debris. Airway epithelia secrete Cl–into the airway surface …
lung from inhaled pathogens and debris. Airway epithelia secrete Cl–into the airway surface …
Cystic fibrosis and Pseudomonas aeruginosa: the host-microbe interface
In human pathophysiology, the clash between microbial infection and host immunity
contributes to multiple diseases. Cystic fibrosis (CF) is a classical example of this …
contributes to multiple diseases. Cystic fibrosis (CF) is a classical example of this …
Cystic fibrosis: a review
T Ong, BW Ramsey - Jama, 2023 - jamanetwork.com
Importance Cystic fibrosis, a genetic disorder defined by variants in the cystic fibrosis
transmembrane conductance regulator (CFTR) gene, affects more than 30 000 individuals in …
transmembrane conductance regulator (CFTR) gene, affects more than 30 000 individuals in …
Dental enamel formation and implications for oral health and disease
Dental enamel is the hardest and most mineralized tissue in extinct and extant vertebrate
species and provides maximum durability that allows teeth to function as weapons and/or …
species and provides maximum durability that allows teeth to function as weapons and/or …
From CFTR biology toward combinatorial pharmacotherapy: expanded classification of cystic fibrosis mutations
G Veit, RG Avramescu, AN Chiang… - Molecular biology of …, 2016 - Am Soc Cell Biol
More than 2000 mutations in the cystic fibrosis transmembrane conductance regulator
(CFTR) have been described that confer a range of molecular cell biological and functional …
(CFTR) have been described that confer a range of molecular cell biological and functional …
Commensal fungi in health and disease
JJ Limon, JH Skalski, DM Underhill - Cell host & microbe, 2017 - cell.com
Fungi are increasingly being recognized as common members of the microbiomes found on
nearly all mucosal surfaces, and interest is growing in understanding how these organisms …
nearly all mucosal surfaces, and interest is growing in understanding how these organisms …