Recent advances on cell culture platforms for in vitro drug screening and cell therapies: from conventional to microfluidic strategies
BD Cardoso, EMS Castanheira… - Advanced …, 2023 - Wiley Online Library
The clinical translations of drugs and nanomedicines depend on coherent pharmaceutical
research based on biologically accurate screening approaches. Since establishing the 2D in …
research based on biologically accurate screening approaches. Since establishing the 2D in …
Current trends in the design of scaffolds for computer-aided tissue engineering
Advances introduced by additive manufacturing have significantly improved the ability to
tailor scaffold architecture, enhancing the control over microstructural features. This has led …
tailor scaffold architecture, enhancing the control over microstructural features. This has led …
Microfluidic cell culture systems for drug research
MH Wu, SB Huang, GB Lee - Lab on a Chip, 2010 - pubs.rsc.org
In pharmaceutical research, an adequate cell-based assay scheme to efficiently screen and
to validate potential drug candidates in the initial stage of drug discovery is crucial. In order …
to validate potential drug candidates in the initial stage of drug discovery is crucial. In order …
Biomaterial delivery of morphogens to mimic the natural healing cascade in bone
Complications in treatment of large bone defects using bone grafting still remain. Our
understanding of the endogenous bone regeneration cascade has inspired the exploration …
understanding of the endogenous bone regeneration cascade has inspired the exploration …
High throughput methods applied in biomaterial development and discovery
The high throughput discovery of new bio materials can be achieved by rapidly screening
many different materials synthesised by a combinatorial approach to identify the optimal …
many different materials synthesised by a combinatorial approach to identify the optimal …
A versatile approach to high-throughput microarrays using thiol-ene chemistry
N Gupta, BF Lin, LM Campos, MD Dimitriou… - Nature …, 2010 - nature.com
Microarray technology has become extremely useful in expediting the investigation of large
libraries of materials in a variety of biomedical applications, such as in DNA chips, protein …
libraries of materials in a variety of biomedical applications, such as in DNA chips, protein …
Interactions between cells or proteins and surfaces exhibiting extreme wettabilities
Regulation of protein adsorption and cell adhesion on surfaces is a key aspect in the field of
biomedicine and tissue engineering. Beside the general studies on hydrophilic/hydrophobic …
biomedicine and tissue engineering. Beside the general studies on hydrophilic/hydrophobic …
Bioprinting 3D cell-laden hydrogel microarray for screening human periodontal ligament stem cell response to extracellular matrix
Y Ma, Y Ji, G Huang, K Ling, X Zhang, F Xu - Biofabrication, 2015 - iopscience.iop.org
Periodontitis is an inflammatory disease negatively affecting up to 15% of adults worldwide.
Periodontal ligament stem cells (PDLSCs) hold great promises for periodontal tissue …
Periodontal ligament stem cells (PDLSCs) hold great promises for periodontal tissue …
Combinatorial and high‐throughput screening of biomaterials
CG Simon Jr, S Lin‐Gibson - Advanced materials, 2011 - Wiley Online Library
Combinatorial and high‐throughput methods have been increasingly used to accelerate
research and development of new biomaterials. These methods involve creating …
research and development of new biomaterials. These methods involve creating …
High-throughput evaluation of interactions between biomaterials, proteins and cells using patterned superhydrophobic substrates
We propose a new low cost platform for high-throughput analysis that permits screening the
biological performance of independent combinations of biomaterials, cells and culture …
biological performance of independent combinations of biomaterials, cells and culture …