Recent advances on cell culture platforms for in vitro drug screening and cell therapies: from conventional to microfluidic strategies

BD Cardoso, EMS Castanheira… - Advanced …, 2023 - Wiley Online Library
The clinical translations of drugs and nanomedicines depend on coherent pharmaceutical
research based on biologically accurate screening approaches. Since establishing the 2D in …

Current trends in the design of scaffolds for computer-aided tissue engineering

SM Giannitelli, D Accoto, M Trombetta, A Rainer - Acta biomaterialia, 2014 - Elsevier
Advances introduced by additive manufacturing have significantly improved the ability to
tailor scaffold architecture, enhancing the control over microstructural features. This has led …

Microfluidic cell culture systems for drug research

MH Wu, SB Huang, GB Lee - Lab on a Chip, 2010 - pubs.rsc.org
In pharmaceutical research, an adequate cell-based assay scheme to efficiently screen and
to validate potential drug candidates in the initial stage of drug discovery is crucial. In order …

Biomaterial delivery of morphogens to mimic the natural healing cascade in bone

M Mehta, K Schmidt-Bleek, GN Duda… - Advanced drug delivery …, 2012 - Elsevier
Complications in treatment of large bone defects using bone grafting still remain. Our
understanding of the endogenous bone regeneration cascade has inspired the exploration …

High throughput methods applied in biomaterial development and discovery

AL Hook, DG Anderson, R Langer, P Williams… - Biomaterials, 2010 - Elsevier
The high throughput discovery of new bio materials can be achieved by rapidly screening
many different materials synthesised by a combinatorial approach to identify the optimal …

A versatile approach to high-throughput microarrays using thiol-ene chemistry

N Gupta, BF Lin, LM Campos, MD Dimitriou… - Nature …, 2010 - nature.com
Microarray technology has become extremely useful in expediting the investigation of large
libraries of materials in a variety of biomedical applications, such as in DNA chips, protein …

Interactions between cells or proteins and surfaces exhibiting extreme wettabilities

W Song, JF Mano - Soft Matter, 2013 - pubs.rsc.org
Regulation of protein adsorption and cell adhesion on surfaces is a key aspect in the field of
biomedicine and tissue engineering. Beside the general studies on hydrophilic/hydrophobic …

Bioprinting 3D cell-laden hydrogel microarray for screening human periodontal ligament stem cell response to extracellular matrix

Y Ma, Y Ji, G Huang, K Ling, X Zhang, F Xu - Biofabrication, 2015 - iopscience.iop.org
Periodontitis is an inflammatory disease negatively affecting up to 15% of adults worldwide.
Periodontal ligament stem cells (PDLSCs) hold great promises for periodontal tissue …

Combinatorial and high‐throughput screening of biomaterials

CG Simon Jr, S Lin‐Gibson - Advanced materials, 2011 - Wiley Online Library
Combinatorial and high‐throughput methods have been increasingly used to accelerate
research and development of new biomaterials. These methods involve creating …

High-throughput evaluation of interactions between biomaterials, proteins and cells using patterned superhydrophobic substrates

AI Neto, CA Custódio, W Song, JF Mano - Soft Matter, 2011 - pubs.rsc.org
We propose a new low cost platform for high-throughput analysis that permits screening the
biological performance of independent combinations of biomaterials, cells and culture …