Adenosine is a ubiquitous endogenous modulator with the main function of maintaining
cellular and tissue homeostasis in pathological and stress conditions. It exerts its effect …

Parkinson's disease (PD) is one of the most debilitating brain diseases. Despite the
availability of symptomatic treatments, response towards the health of PD patients remains …

Adenosine is involved in a range of physiological and pathological effects through
membrane-bound receptors linked to G proteins. There are four subtypes of adenosine …

This paper reviews the results of studies conducted on the role of caffeine in the
management of different neurological disorders, such as Parkinson's disease (PD) and …

Adenosine is an endogenous purine-based nucleoside expressed nearly in all body tissues.
It regulates various body functions by activating four G-protein coupled receptors, A 1, A 2A …

Adenosine exerts an important role in the modulation of central nervous system (CNS)
activity. Through the interaction with four G-protein coupled receptor (GPCR) subtypes …

In modern societies, with an increase in the older population, age-related
neurodegenerative diseases have progressively become greater socioeconomic burdens …

Apathy is a highly prevalent symptom of dementia. Despite its association with faster
cognitive and functional decline, decreased quality of life and increased mortality, no …

Parkinson's disease (PD) is the second-most common progressive neurodegenerative
disorder. Although the clinical diagnosis of PD is still based on its cardinal motor …

Adenosine is a constituent of many molecules of life; increased free extracellular adenosine
indicates cell damage or metabolic stress. The importance of adenosine signaling in basal …