Bilirubin toxicity in the developing nervous system
SM Shapiro - Pediatric neurology, 2003 - Elsevier
Bilirubin toxicity remains a significant problem despite recent advances in the care of
jaundiced (hyperbilirubinemic) neonates. A recent surge in reported cases of classical …
jaundiced (hyperbilirubinemic) neonates. A recent surge in reported cases of classical …
Molecular physiology and pathophysiology of bilirubin handling by the blood, liver, intestine, and brain in the newborn
TWR Hansen, RJ Wong… - Physiological …, 2020 - journals.physiology.org
Bilirubin is the end product of heme catabolism formed during a process that involves
oxidation-reduction reactions and conserves iron body stores. Unconjugated …
oxidation-reduction reactions and conserves iron body stores. Unconjugated …
Neurobehavioral deficits in premature graduates of intensive care—potential medical and neonatal environmental risk factors
JM Perlman - Pediatrics, 2001 - publications.aap.org
There is growing evidence that a large number of very low birth weight infants are exhibiting
neurobehavioral problems in the absence of cerebral palsy at follow-up that has extended …
neurobehavioral problems in the absence of cerebral palsy at follow-up that has extended …
Toward understanding kernicterus: a challenge to improve the management of jaundiced newborns
RP Wennberg, CE Ahlfors, VK Bhutani… - …, 2006 - publications.aap.org
PURPOSE. We sought to evaluate the sensitivity and specificity of total serum bilirubin
concentration (TSB) and free (unbound) bilirubin concentration (Bf) as predictors of risk for …
concentration (TSB) and free (unbound) bilirubin concentration (Bf) as predictors of risk for …
Management of hyperbilirubinemia in the newborn infant 35 or more weeks of gestation
Subcommittee on Hyperbilirubinemia - Pediatrics, 2004 - publications.aap.org
Jaundice occurs in most newborn infants. Most jaundice is benign, but because of the
potential toxicity of bilirubin, newborn infants must be monitored to identify those who might …
potential toxicity of bilirubin, newborn infants must be monitored to identify those who might …
The clinical syndrome of bilirubin-induced neurologic dysfunction
VK Bhutani, L Johnson-Hamerman - Seminars in Fetal and Neonatal …, 2015 - Elsevier
Clinicians have hypothesized a spectrum of minor neurologic manifestations, consistent with
neuroanatomical reports and collectively termed as a “syndrome of bilirubin-induced …
neuroanatomical reports and collectively termed as a “syndrome of bilirubin-induced …
The evolving landscape of neurotoxicity by unconjugated bilirubin: role of glial cells and inflammation
D Brites - Frontiers in pharmacology, 2012 - frontiersin.org
Unconjugated hyperbilirubinemia is a common condition in the first week of postnatal life.
Although generally harmless, some neonates may develop very high levels of unconjugated …
Although generally harmless, some neonates may develop very high levels of unconjugated …
“Auditory neuropathy”: physiologic and pathologic evidence calls for more diagnostic specificity
I Rapin, J Gravel - International journal of pediatric otorhinolaryngology, 2003 - Elsevier
The term “auditory neuropathy” is being used in a rapidly increasing number of papers in the
audiology/otolaryngology literature for a variety of individuals (mostly children) who fulfill the …
audiology/otolaryngology literature for a variety of individuals (mostly children) who fulfill the …
Changes in globus pallidus with (pre) term kernicterus
Objective. We report serial magnetic resonance (MR) and sonographic behavior of globus
pallidus in 5 preterm and 3 term infants with kernicterus and describe the clinical context in …
pallidus in 5 preterm and 3 term infants with kernicterus and describe the clinical context in …
Unbound (free) bilirubin: improving the paradigm for evaluating neonatal jaundice
CE Ahlfors, RP Wennberg, JD Ostrow… - Clinical …, 2009 - academic.oup.com
Background: The serum or plasma total bilirubin concentration (BT) has long been the
standard clinical laboratory test for evaluating neonatal jaundice, despite studies showing …
standard clinical laboratory test for evaluating neonatal jaundice, despite studies showing …