DDX3 DEAD-box RNA helicase (Hel67) gene disruption impairs infectivity of Leishmania donovani and induces protective immunity against visceral leishmaniasis
Visceral leishmaniasis (VL) is a vector-borne disease caused by the digenetic protozoan
parasite Leishmania donovani complex. So far there is no effective vaccine available …
parasite Leishmania donovani complex. So far there is no effective vaccine available …
Evaluation of target-specific natural compounds for drug discovery against leishmaniasis
V Gouri, S Upreti, M Samant - Parasitology International, 2022 - Elsevier
Leishmaniasis is a parasitic disease with no effective vaccine still now. Globally, it has
affected millions of people, precisely in the undeveloped and developing countries. The …
affected millions of people, precisely in the undeveloped and developing countries. The …
Leishmanicidal activity and 4D quantitative structure–activity relationship and molecular docking studies of vanillin-containing 1, 2, 3-triazole derivatives
PA Rodrigues Gazolla, WP Lima… - Future Medicinal …, 2024 - Taylor & Francis
Aim: The assessment of the antileishmanial potential of 22 vanillin-containing 1, 2, 3-triazole
derivatives against Leishmania braziliensis is reported. Materials & methods: Initial …
derivatives against Leishmania braziliensis is reported. Materials & methods: Initial …
[PDF][PDF] Synthesis, Antileishmanial Activity, and in silico Study of 2-Hydroxy-3-(1, 2, 3-triazolyl) propyl Vanillin Derivatives
SS Santiago, CS Freitas, AV Costa… - J. Braz …, 2025 - s3.sa-east-1.amazonaws.com
This study details the preparation, antileishmanial assay, and in silico analysis of twenty 2-
hydroxy-3-(1, 2, 3-triazolyl) propyl vanillin derivatives. These compounds were synthesized …
hydroxy-3-(1, 2, 3-triazolyl) propyl vanillin derivatives. These compounds were synthesized …
In Vitro Antileishmanial Activity of the Essential Oil from Agrimonia pilosa
The search for new herbal-based immune-pharmacological agents for the treatment of
several infectious diseases caused by fungi, bacteria, and protozoa, such as leishmaniasis …
several infectious diseases caused by fungi, bacteria, and protozoa, such as leishmaniasis …
[HTML][HTML] Síntese, atividade antileshmania e citotóxica de hidrazonas derivadas de aldeídos naturais
DCM Souza, VC Sousa, LPL Cruz, SMP Carneiro… - Química …, 2020 - SciELO Brasil
Leishmaniasis is endemic anthropozoonosis considered to be a severe public health
problem. The treatment with pentavalent antimonials presents high toxicity motivating the …
problem. The treatment with pentavalent antimonials presents high toxicity motivating the …
Novel nanotechnology-based approaches in the treatment of leishmaniasis
K Dasauni, D Bisht, TK Nailwal - Pathogenesis, Treatment and Prevention …, 2021 - Elsevier
Leishmaniasis is an infectious parasitic disease caused by Leishmania. There are more
than 21 species that cause human infections, and 12 million people worldwide are infected …
than 21 species that cause human infections, and 12 million people worldwide are infected …
Cheminformatics Screening of Phytochemicals Targeting Diverse Potential Receptors to Elicit Antiviral Properties
Objective: Recently, the COVID-19 (coronavirus disease) pandemic caused by SARSCoV-2
(severe acute respiratory syndrome coronavirus) gave rise to a public health emergency …
(severe acute respiratory syndrome coronavirus) gave rise to a public health emergency …
Unveiling the Targets Involved in the Quest of Antileishmanial Leads Using In silico Methods
PK Boniface, CM Sano, FI Elizabeth - Current Drug Targets, 2020 - ingentaconnect.com
Background: Leishmaniasis is a neglected tropical disease associated with several clinical
manifestations, including cutaneous, mucocutaneous, and visceral forms. As currently …
manifestations, including cutaneous, mucocutaneous, and visceral forms. As currently …
DNA microarray analysis of Leishmania parasite: strengths and limitations
Leishmaniasis affects the poorest of the poor across the globe. The present treatment is not
quite effective. The troubling increase in drug resistance and the inaccessibility of an …
quite effective. The troubling increase in drug resistance and the inaccessibility of an …