DDX3 DEAD-box RNA helicase (Hel67) gene disruption impairs infectivity of Leishmania donovani and induces protective immunity against visceral leishmaniasis

SC Pandey, V Pande, M Samant - Scientific reports, 2020 - nature.com
Visceral leishmaniasis (VL) is a vector-borne disease caused by the digenetic protozoan
parasite Leishmania donovani complex. So far there is no effective vaccine available …

Evaluation of target-specific natural compounds for drug discovery against leishmaniasis

V Gouri, S Upreti, M Samant - Parasitology International, 2022 - Elsevier
Leishmaniasis is a parasitic disease with no effective vaccine still now. Globally, it has
affected millions of people, precisely in the undeveloped and developing countries. The …

Leishmanicidal activity and 4D quantitative structure–activity relationship and molecular docking studies of vanillin-containing 1, 2, 3-triazole derivatives

PA Rodrigues Gazolla, WP Lima… - Future Medicinal …, 2024 - Taylor & Francis
Aim: The assessment of the antileishmanial potential of 22 vanillin-containing 1, 2, 3-triazole
derivatives against Leishmania braziliensis is reported. Materials & methods: Initial …

[PDF][PDF] Synthesis, Antileishmanial Activity, and in silico Study of 2-Hydroxy-3-(1, 2, 3-triazolyl) propyl Vanillin Derivatives

SS Santiago, CS Freitas, AV Costa… - J. Braz …, 2025 - s3.sa-east-1.amazonaws.com
This study details the preparation, antileishmanial assay, and in silico analysis of twenty 2-
hydroxy-3-(1, 2, 3-triazolyl) propyl vanillin derivatives. These compounds were synthesized …

In Vitro Antileishmanial Activity of the Essential Oil from Agrimonia pilosa

DS Dhami, SC Pandey, GC Shah, M Bisht… - National Academy …, 2021 - Springer
The search for new herbal-based immune-pharmacological agents for the treatment of
several infectious diseases caused by fungi, bacteria, and protozoa, such as leishmaniasis …

[HTML][HTML] Síntese, atividade antileshmania e citotóxica de hidrazonas derivadas de aldeídos naturais

DCM Souza, VC Sousa, LPL Cruz, SMP Carneiro… - Química …, 2020 - SciELO Brasil
Leishmaniasis is endemic anthropozoonosis considered to be a severe public health
problem. The treatment with pentavalent antimonials presents high toxicity motivating the …

Novel nanotechnology-based approaches in the treatment of leishmaniasis

K Dasauni, D Bisht, TK Nailwal - Pathogenesis, Treatment and Prevention …, 2021 - Elsevier
Leishmaniasis is an infectious parasitic disease caused by Leishmania. There are more
than 21 species that cause human infections, and 12 million people worldwide are infected …

Cheminformatics Screening of Phytochemicals Targeting Diverse Potential Receptors to Elicit Antiviral Properties

R Kumar, G Gupta, A Mohan, M Gupta - Coronaviruses, 2024 - benthamdirect.com
Objective: Recently, the COVID-19 (coronavirus disease) pandemic caused by SARSCoV-2
(severe acute respiratory syndrome coronavirus) gave rise to a public health emergency …

Unveiling the Targets Involved in the Quest of Antileishmanial Leads Using In silico Methods

PK Boniface, CM Sano, FI Elizabeth - Current Drug Targets, 2020 - ingentaconnect.com
Background: Leishmaniasis is a neglected tropical disease associated with several clinical
manifestations, including cutaneous, mucocutaneous, and visceral forms. As currently …

DNA microarray analysis of Leishmania parasite: strengths and limitations

SC Pandey, S Gangola, S Kumar, P Debborma… - … and Prevention of …, 2021 - Elsevier
Leishmaniasis affects the poorest of the poor across the globe. The present treatment is not
quite effective. The troubling increase in drug resistance and the inaccessibility of an …