Advances of phytotherapy in ischemic stroke targeting PI3K/Akt signaling

T Liu, W Wang, X Li, Y Chen, F Mu, A Wen… - Phytotherapy …, 2023 - Wiley Online Library
The pathogenesis of ischemic stroke is complex, and PI3K/Akt signaling is considered to
play a crucial role in it. The PI3K/Akt pathway regulates inflammation, oxidative stress …

Nuciferine reduces inflammation induced by cerebral ischemia-reperfusion injury through the PI3K/Akt/NF-κB pathway

J Li, S Dong, S Quan, S Ding, X Zhou, Y Yu, Y Wu… - Phytomedicine, 2024 - Elsevier
Background Cerebral ischemia has the characteristics of high incidence, mortality, and
disability, which seriously damages people's health. Cerebral ischemia-reperfusion injury is …

Efficient biogenesis of calcium oxide nanoparticles using the extract of Eleusine coracana seeds and their application against multidrug-resistant ocular bacterial …

S Devanesan, HA David, AJ Ranjitsingh… - Environmental …, 2024 - Elsevier
Visual impairment due to corneal keratitis-causing bacteria is becoming a matter of health
concern. The bacterial colonization and their resistance to multiple drugs need imperative …

A review on the phytochemistry and biological activities of Curculigo latifolia Dryand ex. W.Aiton

AY Taufik, H Mohd Yasin, N Ahmad, M Arai… - …, 2024 - f1000research.com
Curculigo latifolia Dryand. ex WT Aiton, from the genus Curculigo, is a medicinal plant
traditionally used to treat numerous illnesses such as fever, stomach aches, jaundice …

[HTML][HTML] Neuroprotective effects of Jie-du-huo-xue decoction on microglia pyroptosis after cerebral ischemia and reperfusion——From the perspective of glial-vascular …

C Zhou, J Li, C Zheng, X Zhou, C Chen, S Qiu… - Journal of …, 2024 - Elsevier
Ethnopharmacological relevance Ischemic stroke poses a serious risk to public health and
quality of life. Jie-Du-Huo-Xue decoction (JDHXD) is a classical and well-known Chinese …

[HTML][HTML] TGR5 signalling in heart and brain injuries: focus on metabolic and ischaemic mechanisms

N Xu, Y He, C Zhang, Y Zhang, S Cheng, L Deng… - Neurobiology of …, 2024 - Elsevier
The heart and brain are the core organs of the circulation and central nervous system,
respectively, and play an important role in maintaining normal physiological functions. Early …

Bombyx batryticatus extract activates coagulation factor Ⅻ to promote angiogenesis in rats with cerebral ischemia/reperfusion injury

S Wang, H Xu, A Ge, K Yang, Q He, J Ge - Journal of Ethnopharmacology, 2024 - Elsevier
Ethnopharmacological relevance Bombyx batryticatus is traditionally used to treat patients
with stroke, but its mechanism remains unclear. Aim of the study To explore the …

Caspase-1 deletion reveals pyroptosis participates in neural damage induced by cerebral ischemia/reperfusion in tMCAO model mice

QN Hao, XB Xue, H Zhou, ZL Hu - NeuroReport, 2024 - journals.lww.com
Pyroptosis, a form of programmed cell death, drives inflammation in the context of cerebral
ischemia/reperfusion. The molecular mechanism of pyroptosis underlying …

Identification of five characteristic ferroptosis-related genes as novel biomarkers for ischemic stroke using bioinformatic and machine learning strategies

X Feng, C Huang, L Ye, Z Xu - bioRxiv, 2023 - biorxiv.org
Ferroptosis is crucial in neuronal cell death, associated with various neurological disorders.
However, the role of ferroptosis-related genes (FRGs) in ischaemic stroke (IS) has yet to be …

Machine Learning Analysis of Gene Expression Profiles ofPyroptosis-Related Differentially Expressed Genes in IschemicStroke Revealed Potential Targets for Drug …

C Hei, X Li, R Wang, P Liu, X Dong, PA Li, W Zheng… - 2023 - researchsquare.com
The relationship between ischemic stroke (IS) and pyroptosis centers on the inflammatory
response elicited by cerebral tissue damage during an ischemic stroke event. However, an …