Diabetic kidney disease (DKD) is a major microvascular complication of diabetes and a
common cause of end-stage renal disease worldwide. DKD manifests as an increased …

Background: Phytochemicals are obtained from various plants and used for the treatment of
diseases as both traditional and modern medicines. Poor bioavailability of phytochemicals is …

Cynodon dactylon is a potential source of metabolites such as flavanoids, alkaloids,
glycosides and β-sitosterol and has been traditionally employed to treat urinary tract and …

A wealth of epidemiological data has found that patients with type 2 diabetes have a greater
risk of developing breast cancer. The molecular mechanisms underpinning this relationship …

Insulin promotes glucose uptake into skeletal muscle through recruitment of glucose
transporter 4 (GLUT4) to the plasma membrane. Rab GTPases are molecular switches …

Dynamin-2 is a ubiquitously expressed GTP-ase that mediates membrane remodeling.
Recent findings indicate that dynamin-2 also regulates actin dynamics. Mutations in …

Precise matching of energy substrate delivery to local metabolic needs is essential for the
health and function of all tissues. Here, we outline a mechanistic framework for …

Key points The molecular and cellular mechanisms involved in short‐term regulation of
white adipocyte adipokine release remain elusive. Here we have examined effects of …

Type 2 diabetes is characterised by failure to control glucose homeostasis, with numerous
diabetic complications attributable to the resulting exposure of cells and tissues to chronic …

Kaempferol possesses various health-promoting functions including antihyperglycemic
activity, but its underlying molecular mechanism is poorly understood. Glucose transporter 4 …