Exocytosis proteins as novel targets for diabetes prevention and/or remediation?

A Aslamy, DC Thurmond - American Journal of Physiology …, 2017 - journals.physiology.org
Diabetes remains one of the leading causes of morbidity and mortality worldwide, affecting
an estimated 422 million adults. In the US, it is predicted that one in every three children …

Phosphorylation of the exocyst protein Exo84 by TBK1 promotes insulin-stimulated GLUT4 trafficking

M Uhm, M Bazuine, P Zhao, SH Chiang, T Xiong… - Science …, 2017 - science.org
Insulin stimulates glucose uptake through the translocation of the glucose transporter
GLUT4 to the plasma membrane. The exocyst complex tethers GLUT4-containing vesicles to …

Mung bean peptides promote glucose uptake via Jak2 activation in L6 myotubes

Y Yoshioka, Q Zhang, X Wang, T Kitakaze… - Food & Function, 2023 - pubs.rsc.org
Mung beans are among the important edible legumes cultivated in Asia, Southern Europe,
and Northern America. Mung beans contain 20–30% proteins with high digestibility and …

Metabolism and pharmacokinetics of phytochemicals in the human body

P Rathaur, KJ SR - Current drug metabolism, 2019 - ingentaconnect.com
Background: Phytochemicals are obtained from various plants and used for the treatment of
diseases as both traditional and modern medicines. Poor bioavailability of phytochemicals is …

Quantitative immunofluorescence microscopy of subcellular GLUT 4 distribution in human skeletal muscle: Effects of endurance and sprint interval training

H Bradley, CS Shaw, PL Worthington… - Physiological …, 2014 - Wiley Online Library
Increases in insulin‐mediated glucose uptake following endurance training (ET) and sprint
interval training (SIT) have in part been attributed to concomitant increases in glucose …

CircRNA hsa_circ_0071336 is associated with type 2 diabetes through targeting the miR‐93‐5p/GLUT4 axis

YX Yan, J Dong, YL Li, YK Lu, K Yang… - The FASEB …, 2022 - Wiley Online Library
Abstract Glucose transporter 4 (GLUT4) is a dominant regulator of whole‐body glucose
homeostasis. Accumulating evidence has shown that circular RNAs (circRNAs) play …

The hypothalamus as a key regulator of glucose homeostasis: emerging roles of the brain renin-angiotensin system

S Pan, CJ Worker… - American Journal of …, 2023 - journals.physiology.org
The regulation of plasma glucose levels is a complex and multifactorial process involving a
network of receptors and signaling pathways across numerous organs that act in concert to …

Trafficking regulator of GLUT4-1 (TRARG1) is a GSK3 substrate

X Duan, DM Norris, SJ Humphrey, P Yang… - Biochemical …, 2022 - portlandpress.com
Trafficking regulator of GLUT4-1, TRARG1, positively regulates insulin-stimulated GLUT4
trafficking and insulin sensitivity. However, the mechanism (s) by which this occurs remain …

The carbon/nitrogen regulator ARABIDOPSIS TOXICOS EN LEVADURA31 controls papilla formation in response to powdery mildew fungi penetration by interacting …

S Maekawa, N Inada, S Yasuda, Y Fukao… - Plant …, 2014 - academic.oup.com
The carbon/nitrogen (C/N) balance of plants is not only required for growth and development
but also plays an important role in basal immunity. However, the mechanisms that link C/N …

From physical inactivity to immobilization: Dissecting the role of oxidative stress in skeletal muscle insulin resistance and atrophy

N Pierre, Z Appriou, A Gratas-Delamarche… - Free Radical Biology and …, 2016 - Elsevier
In the literature, the terms physical inactivity and immobilization are largely used as
synonyms. The present review emphasizes the need to establish a clear distinction between …